Gene description for ACSM1
Gene name acyl-CoA synthetase medium-chain family member 1
Gene symbol ACSM1
Other names/aliases BUCS1
MACS1
Species Homo sapiens
 Database cross references - ACSM1
ExoCarta ExoCarta_116285
Entrez Gene 116285
HGNC 18049
MIM 614357
UniProt Q08AH1  
 ACSM1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for ACSM1
Molecular Function
    butyrate-CoA ligase activity GO:0047760 IDA
    GTP binding GO:0005525 IEA
    ATP binding GO:0005524 IEA
    acyl-CoA ligase activity GO:0003996 IDA
    metal ion binding GO:0046872 IEA
    fatty acid ligase activity GO:0015645 IEA
Biological Process
    energy derivation by oxidation of organic compounds GO:0015980 NAS
    small molecule metabolic process GO:0044281 TAS
    butyrate metabolic process GO:0019605 NAS
    cholesterol homeostasis GO:0042632 NAS
    xenobiotic metabolic process GO:0006805 TAS
    fatty acid biosynthetic process GO:0006633 IEA
    benzoate metabolic process GO:0018874 NAS
    fatty acid oxidation GO:0019395 NAS
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    blood microparticle GO:0072562 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ACSM1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ACSM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACSM1 is involved
PathwayEvidenceSource
Conjugation of benzoate with glycine TAS Reactome
Conjugation of phenylacetate with glutamine TAS Reactome





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