Gene description for IFITM2
Gene name interferon induced transmembrane protein 2
Gene symbol IFITM2
Other names/aliases 1-8D
DSPA2c
Species Homo sapiens
 Database cross references - IFITM2
ExoCarta ExoCarta_10581
Entrez Gene 10581
HGNC 5413
MIM 605578
UniProt Q01629  
 IFITM2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IFITM2
Biological Process
    cytokine-mediated signaling pathway GO:0019221 TAS
    type I interferon signaling pathway GO:0060337 TAS
    negative regulation of viral genome replication GO:0045071 IDA
    response to interferon-alpha GO:0035455 IDA
    response to interferon-beta GO:0035456 IDA
    negative regulation of viral entry into host cell GO:0046597 IDA
    response to virus GO:0009615 IDA
    immune response GO:0006955 TAS
    defense response to virus GO:0051607 IEA
    response to interferon-gamma GO:0034341 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified IFITM2 in exosomes
1
Experiment ID 21
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IFITM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPF3A  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IFITM2 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here