Gene description for YTHDC2
Gene name YTH domain containing 2
Gene symbol YTHDC2
Other names/aliases CAHL
Species Homo sapiens
 Database cross references - YTHDC2
ExoCarta ExoCarta_64848
Entrez Gene 64848
HGNC 24721
UniProt Q9H6S0  
 YTHDC2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for YTHDC2
Molecular Function
    ATP-dependent RNA helicase activity GO:0004004 IBA
    ATP binding GO:0005524 IEA
    RNA polymerase binding GO:0070063 IPI
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    RNA-dependent ATPase activity GO:0008186 IDA
Biological Process
    response to interleukin-1 GO:0070555 IDA
    positive regulation by host of viral genome replication GO:0044829 IMP
    response to tumor necrosis factor GO:0034612 IDA
    RNA processing GO:0006396 IBA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified YTHDC2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for YTHDC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which YTHDC2 is involved
No pathways found





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