Experiment description of studies that identified YTHDC2 in exosomes

1 Experiment ID 488 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 36408942     Organism Homo sapiens Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ. Journal name Proteomics Publication year 2023 Sample Mesenchymal stem cells Sample name UCMSC Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 224 MISEV standards ✔ EM|AFM Biophysical techniques ✔ Alix|TSG101|CD63|CD81 Enriched markers ✔ GOLGA2 Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25944692     Organism Homo sapiens Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S Journal name Oncotarget Publication year 2015 Sample Neuroblastoma cells Sample name SH-SY5Y Isolation/purification methods Differential centrifugation Ultracentrifugation OptiPrep density gradient Flotation density 1.10 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting

Protein-protein interactions for YTHDC2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 UBE2H 7328 Affinity Capture-MS Homo sapiens 2 ZBTB38 253461 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 3 SLFN11 91607 Affinity Capture-MS Homo sapiens 4 ZNF668   Affinity Capture-MS Homo sapiens 5 RPL26L1 51121 Affinity Capture-MS Homo sapiens 6 RSL1D1 26156 Affinity Capture-MS Homo sapiens 7 IRF4   Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens 8 ZNF346   Affinity Capture-MS Homo sapiens 9 ZNF324B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 10 TARDBP 23435 Affinity Capture-MS Homo sapiens 11 RPL13A 23521 Affinity Capture-MS Homo sapiens 12 TRIM66   Affinity Capture-MS Homo sapiens 13 RPS19 6223 Affinity Capture-MS Homo sapiens 14 RPL15 6138 Affinity Capture-MS Homo sapiens 15 TNFRSF6B   Affinity Capture-MS Homo sapiens 16 RPL14 9045 Affinity Capture-MS Homo sapiens 17 CAND1 55832 Affinity Capture-MS Homo sapiens 18 FGF3   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 19 SOX2   Affinity Capture-MS Homo sapiens 20 RPS3 6188 Affinity Capture-MS Homo sapiens 21 USP36   Affinity Capture-MS Homo sapiens 22 PARK2   Affinity Capture-MS Homo sapiens 23 RPL10A 4736 Affinity Capture-MS Homo sapiens 24 HEATR3 55027 Affinity Capture-MS Homo sapiens 25 RPL28 6158 Affinity Capture-MS Homo sapiens 26 LLPH   Affinity Capture-MS Homo sapiens 27 KIF23 9493 Affinity Capture-MS Homo sapiens 28 CCDC137   Affinity Capture-MS Homo sapiens 29 COPS5 10987 Affinity Capture-MS Homo sapiens 30 ANOS1 3730 Affinity Capture-MS Homo sapiens 31 FBL 2091 Proximity Label-MS Homo sapiens 32 ZSCAN31   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 33 ADARB1 104 Affinity Capture-MS Homo sapiens 34 PRKRA 8575 Affinity Capture-MS Homo sapiens 35 ATG16L1 55054 Affinity Capture-MS Homo sapiens 36 GSTO1 9446 Co-fractionation Homo sapiens 37 OASL 8638 Affinity Capture-MS Homo sapiens 38 RPL19 6143 Affinity Capture-MS Homo sapiens 39 KIF14 9928 Affinity Capture-MS Homo sapiens 40 LIN28A   Affinity Capture-MS Homo sapiens 41 ZNF550   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 42 SRP9 6726 Affinity Capture-MS Homo sapiens 43 MIB1 57534 Proximity Label-MS Homo sapiens 44 NXPH1   Affinity Capture-MS Homo sapiens 45 DDX21 9188 Affinity Capture-MS Homo sapiens 46 IRAK1   Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens 47 RPL4 6124 Affinity Capture-MS Homo sapiens 48 RPS10 6204 Affinity Capture-MS Homo sapiens 49 RBM4B   Affinity Capture-MS Homo sapiens 50 YBX2 51087 Affinity Capture-MS Homo sapiens 51 APOBEC3C 27350 Affinity Capture-MS Homo sapiens 52 SRSF6 6431 Affinity Capture-MS Homo sapiens 53 PURG   Affinity Capture-MS Homo sapiens 54 NOP2 4839 Affinity Capture-MS Homo sapiens 55 RPL5 6125 Affinity Capture-MS Homo sapiens 56 HIST1H2AM 8336 Affinity Capture-MS Homo sapiens 57 RPL18A 6142 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 58 Srp72   Affinity Capture-MS Mus musculus 59 NTRK1 4914 Affinity Capture-MS Homo sapiens 60 FGF8   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 61 HIST1H1E 3008 Affinity Capture-MS Homo sapiens 62 SYNCRIP 10492 Affinity Capture-MS Homo sapiens 63 ERP29 10961 Cross-Linking-MS (XL-MS) Homo sapiens 64 DCTN1 1639 Proximity Label-MS Homo sapiens 65 RPL36 25873 Affinity Capture-MS Homo sapiens 66 HIST1H1C 3006 Affinity Capture-MS Homo sapiens 67 RPS6 6194 Affinity Capture-MS Homo sapiens 68 HECTD1 25831 Affinity Capture-MS Homo sapiens 69 RPLP0 6175 Affinity Capture-MS Homo sapiens 70 MAGEB2 4113 Affinity Capture-MS Homo sapiens 71 FGF13   Affinity Capture-MS Homo sapiens 72 GLTSCR2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 73 KDF1   Affinity Capture-MS Homo sapiens 74 WDR46   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 75 FGFBP1 9982 Affinity Capture-MS Homo sapiens 76 RRP8   Affinity Capture-MS Homo sapiens 77 TEN1   Affinity Capture-MS Homo sapiens 78 USP42   Affinity Capture-MS Homo sapiens 79 MAP7 9053 Affinity Capture-MS Homo sapiens 80 ABT1 29777 Affinity Capture-MS Homo sapiens 81 RPL7A 6130 Affinity Capture-MS Homo sapiens 82 RC3H2   Affinity Capture-MS Homo sapiens 83 SIRT7   Affinity Capture-MS Homo sapiens 84 SREBF1 6720 Affinity Capture-RNA Homo sapiens 85 CUL3 8452 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 86 Rrbp1   Affinity Capture-MS Mus musculus 87 RPL3 6122 Affinity Capture-MS Homo sapiens 88 RPL7L1 285855 Affinity Capture-MS Homo sapiens 89 MYC   Affinity Capture-MS Homo sapiens 90 HNRNPCL2 440563 Affinity Capture-MS Homo sapiens 91 ZC3H10   Affinity Capture-MS Homo sapiens 92 NXF2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 93 ZNF512   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 94 MYCN   Affinity Capture-MS Homo sapiens 95 HIST1H1B 3009 Affinity Capture-MS Homo sapiens 96 CBX6   Affinity Capture-MS Homo sapiens 97 PARP1 142 Proximity Label-MS Homo sapiens 98 MYO6 4646 Affinity Capture-MS Homo sapiens 99 PSPC1 55269 Affinity Capture-MS Homo sapiens 100 RPA3 6119 Proximity Label-MS Homo sapiens 101 PABPC5 140886 Affinity Capture-MS Homo sapiens 102 RPS14 6208 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 103 ZNF653   Affinity Capture-MS Homo sapiens 104 RPL23A 6147 Affinity Capture-MS Homo sapiens 105 DDRGK1 65992 Affinity Capture-MS Homo sapiens 106 Rpl35 66489 Affinity Capture-MS Mus musculus 107 SIK2   Affinity Capture-MS Homo sapiens 108 ZC3H3   Affinity Capture-MS Homo sapiens 109 RBMS2 5939 Affinity Capture-MS Homo sapiens 110 CCDC8   Affinity Capture-MS Homo sapiens 111 RPS16 6217 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 112 ZNF574   Affinity Capture-MS Homo sapiens 113 RPL13 6137 Affinity Capture-MS Homo sapiens 114 RNF43   Proximity Label-MS Homo sapiens 115 SURF6   Affinity Capture-MS Homo sapiens 116 PLEKHA4 57664 Affinity Capture-MS Homo sapiens 117 FBXW11   Affinity Capture-MS Homo sapiens 118 RNF151   Affinity Capture-MS Homo sapiens 119 SIRT6   Affinity Capture-MS Homo sapiens 120 RBM19 9904 Affinity Capture-MS Homo sapiens 121 ILF3 3609 Affinity Capture-MS Homo sapiens 122 FBXL6   Affinity Capture-MS Homo sapiens 123 MNDA 4332 Affinity Capture-MS Homo sapiens 124 TRIM52   Affinity Capture-MS Homo sapiens 125 ZNF48   Affinity Capture-MS Homo sapiens 126 PRMT1 3276 Affinity Capture-MS Homo sapiens 127 ARHGAP18 93663 Affinity Capture-MS Homo sapiens 128 ZNF764 92595 Affinity Capture-MS Homo sapiens 129 HSP90AA1 3320 Affinity Capture-MS Homo sapiens 130 FKBP5 2289 Affinity Capture-MS Homo sapiens 131 PRR3   Affinity Capture-MS Homo sapiens 132 NIFK 84365 Affinity Capture-MS Homo sapiens 133 SQSTM1 8878 Proximity Label-MS Homo sapiens 134 UFL1 23376 Affinity Capture-MS Homo sapiens 135 LARP7 51574 Affinity Capture-MS Homo sapiens 136 NEIL1   Affinity Capture-MS Homo sapiens 137 GLI4   Affinity Capture-MS Homo sapiens 138 RPL23AP32 56969 Affinity Capture-MS Homo sapiens 139 CLTA 1211 Affinity Capture-MS Homo sapiens 140 RPL31 6160 Affinity Capture-MS Homo sapiens 141 CIT 11113 Affinity Capture-MS Homo sapiens 142 RPL8 6132 Affinity Capture-MS Homo sapiens 143 GRSF1 2926 Proximity Label-MS Homo sapiens 144 PTGES3 10728 Affinity Capture-MS Homo sapiens 145 SNW1 22938 Affinity Capture-MS Homo sapiens 146 HNRNPU 3192 Affinity Capture-MS Homo sapiens 147 RC3H1 149041 Affinity Capture-MS Homo sapiens 148 TNNT3   Affinity Capture-MS Homo sapiens 149 ZNF467   Affinity Capture-MS Homo sapiens 150 HIST1H2AE 3012 Affinity Capture-MS Homo sapiens 151 RPL17 6139 Affinity Capture-MS Homo sapiens View the network

Pathways in which YTHDC2 is involved

No pathways found