Gene description for ZBTB38
Gene name zinc finger and BTB domain containing 38
Gene symbol ZBTB38
Other names/aliases CIBZ
PPP1R171
ZNF921
Species Homo sapiens
 Database cross references - ZBTB38
ExoCarta ExoCarta_253461
Vesiclepedia VP_253461
Entrez Gene 253461
HGNC 26636
MIM 612218
UniProt Q8NAP3  
 ZBTB38 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZBTB38
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity GO:0003700 ISS
    protein binding GO:0005515 IPI
    methyl-CpG binding GO:0008327 IDA
    protein homodimerization activity GO:0042803 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of DNA replication GO:0006275 IMP
    regulation of DNA-templated transcription GO:0006355 IBA
    DNA damage response GO:0006974 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified ZBTB38 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZBTB38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 DDX18 8886
Affinity Capture-MS Homo sapiens
3 ELAVL2 1993
Affinity Capture-MS Homo sapiens
4 RALBP1 10928
Two-hybrid Homo sapiens
5 RBBP6 5930
Two-hybrid Homo sapiens
6 FSD2 123722
Two-hybrid Homo sapiens
7 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RSBN1L  
Affinity Capture-MS Homo sapiens
9 ZNF689  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CBFA2T3  
Two-hybrid Homo sapiens
11 RPS3A 6189
Affinity Capture-MS Homo sapiens
12 DHX36 170506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 POP1 10940
Affinity Capture-MS Homo sapiens
14 IPO7 10527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 YTHDC2 64848
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MRPS35 60488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRIM41 90933
Two-hybrid Homo sapiens
18 TCOF1 6949
Affinity Capture-MS Homo sapiens
19 SDAD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RPL15 6138
Affinity Capture-MS Homo sapiens
22 TRIM26 7726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MECP2 4204
Affinity Capture-MS Homo sapiens
24 RSBN1  
Affinity Capture-MS Homo sapiens
25 SIRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SPTY2D1  
Affinity Capture-MS Homo sapiens
27 STAU1 6780
Affinity Capture-MS Homo sapiens
28 LZTS2 84445
Two-hybrid Homo sapiens
29 PTCD3 55037
Affinity Capture-MS Homo sapiens
30 NOC2L 26155
Affinity Capture-MS Homo sapiens
31 ZCCHC17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 Mis12  
Affinity Capture-MS Mus musculus
33 DDX24 57062
Affinity Capture-MS Homo sapiens
34 PDE4DIP 9659
Two-hybrid Homo sapiens
35 EHMT2 10919
Two-hybrid Homo sapiens
36 MRPS5 64969
Affinity Capture-MS Homo sapiens
37 KRT40  
Two-hybrid Homo sapiens
38 CCDC136  
Two-hybrid Homo sapiens
39 EIF5B 9669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 MTUS2 23281
Two-hybrid Homo sapiens
41 NEMF 9147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
43 LRR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TSGA10  
Two-hybrid Homo sapiens
45 SRPK1 6732
Affinity Capture-MS Homo sapiens
46 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB38 is involved
No pathways found





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