Gene description for TRMT10A
Gene name tRNA methyltransferase 10 homolog A (S. cerevisiae)
Gene symbol TRMT10A
Other names/aliases HEL-S-88
MSSGM
RG9MTD2
TRM10
Species Homo sapiens
 Database cross references - TRMT10A
ExoCarta ExoCarta_93587
Vesiclepedia VP_93587
Entrez Gene 93587
HGNC 28403
MIM 616013
UniProt Q8TBZ6  
 TRMT10A identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TRMT10A
Molecular Function
    tRNA binding GO:0000049 IBA
    tRNA binding GO:0000049 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    tRNA (guanosine(9)-N1)-methyltransferase activity GO:0052905 IDA
    tRNA (guanosine(9)-N1)-methyltransferase activity GO:0052905 IMP
Biological Process
    tRNA N1-guanine methylation GO:0002939 IBA
    tRNA N1-guanine methylation GO:0002939 IMP
    tRNA methylation GO:0030488 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    actin cytoskeleton GO:0015629 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TRMT10A in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TRMT10A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AARSD1 80755
Co-fractionation Homo sapiens
2 SH3GL1 6455
Co-fractionation Homo sapiens
3 CALU 813
Co-fractionation Homo sapiens
4 ARPC3 10094
Co-fractionation Homo sapiens
5 PPP2R5E 5529
Co-fractionation Homo sapiens
6 PRKACA 5566
Co-fractionation Homo sapiens
7 Rfx5  
Affinity Capture-MS Mus musculus
8 ZBTB33  
Affinity Capture-MS Homo sapiens
9 DEK 7913
Co-fractionation Homo sapiens
10 TRIM7  
Two-hybrid Homo sapiens
11 SYT2  
Affinity Capture-MS Homo sapiens
12 MAD2L1 4085
Affinity Capture-MS Homo sapiens
13 Myh9 17886
Affinity Capture-MS Mus musculus
14 SNRNP70 6625
Co-fractionation Homo sapiens
15 ARPC5L 81873
Co-fractionation Homo sapiens
16 RANGAP1 5905
Co-fractionation Homo sapiens
17 ARL6IP1 23204
Cross-Linking-MS (XL-MS) Homo sapiens
18 SAE1 10055
Co-fractionation Homo sapiens
19 SF3B1 23451
Co-fractionation Homo sapiens
20 ATP2A2 488
Cross-Linking-MS (XL-MS) Homo sapiens
21 ARPC1A 10552
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which TRMT10A is involved
PathwayEvidenceSource
Metabolism of RNA IEA Reactome
tRNA modification in the nucleus and cytosol IEA Reactome
tRNA processing IEA Reactome





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