Gene description for Sirt2
Gene name sirtuin 2
Gene symbol Sirt2
Other names/aliases 5730427M03Rik
SIR2L2
Sir2l
Species Mus musculus
 Database cross references - Sirt2
ExoCarta ExoCarta_64383
Entrez Gene 64383
UniProt Q8VDQ8  
 Sirt2 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Sirt2
Molecular Function
    4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity GO:0034571 IEA
    protein binding GO:0005515 IPI
    NAD-dependent protein deacetylase activity GO:0034979 ISO
    zinc ion binding GO:0008270 ISO
    didemethylisoproturon amidohydrolase activity GO:0034573 IEA
    NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 ISO
    protein deacetylase activity GO:0033558 ISO
    beta-tubulin binding GO:0048487 IDA
    hydrolase activity GO:0016787 IEA
    protein-N-terminal asparagine amidohydrolase activity GO:0008418 IEA
    N-cyclohexylformamide amidohydrolase activity GO:0034781 IEA
    cis-aconitamide amidase activity GO:0034882 IEA
    metal ion binding GO:0046872 IEA
    indoleacetamide hydrolase activity GO:0043864 IEA
    diacetylchitobiose deacetylase activity GO:0052773 IEA
    histone deacetylase binding GO:0042826 ISO
    chromatin binding GO:0003682 ISO
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GO:0008759 IEA
    transcription factor binding GO:0008134 ISO
    histone acetyltransferase binding GO:0035035 ISO
    N2-acetyl-L-lysine deacetylase activity GO:0043747 IEA
    NAD+ binding GO:0070403 ISO
    gamma-N-formylaminovinylacetate hydrolase activity GO:0034885 IEA
    histone deacetylase activity GO:0004407 ISO
    iprodione amidohydrolase activity GO:0018748 IEA
    N-acetylcitrulline deacetylase activity GO:0043909 IEA
    (3,5-dichlorophenylurea)acetate amidohydrolase activity GO:0018749 IEA
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 IEA
    isonicotinic acid hydrazide hydrolase activity GO:0034876 IEA
    NAD binding GO:0051287 IEA
    ubiquitin binding GO:0043130 ISO
    tubulin deacetylase activity GO:0042903 ISO
    O-succinylbenzoate synthase activity GO:0043748 IEA
    N-acetylgalactosamine-6-phosphate deacetylase activity GO:0047419 IEA
    N-isopropylacetanilide amidohydrolase activity GO:0034576 IEA
    chitooligosaccharide deacetylase activity GO:0052790 IEA
Biological Process
    negative regulation of peptidyl-threonine phosphorylation GO:0010801 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    cellular response to hepatocyte growth factor stimulus GO:0035729 ISO
    histone H4 deacetylation GO:0070933 ISO
    mitotic nuclear division GO:0007067 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IMP
    positive regulation of execution phase of apoptosis GO:1900119 IMP
    positive regulation of meiotic nuclear division GO:0045836 IMP
    cellular response to oxidative stress GO:0034599 IDA
    protein kinase B signaling GO:0043491 ISO
    cell division GO:0051301 IEA
    tubulin deacetylation GO:0090042 ISO
    peptidyl-lysine deacetylation GO:0034983 ISO
    negative regulation of oligodendrocyte progenitor proliferation GO:0070446 ISO
    negative regulation of defense response to bacterium GO:1900425 ISO
    protein deacetylation GO:0006476 ISO
    positive regulation of oocyte maturation GO:1900195 IMP
    negative regulation of cell proliferation GO:0008285 ISO
    positive regulation of cell division GO:0051781 IMP
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IMP
    cellular response to epinephrine stimulus GO:0071872 IDA
    positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 IMP
    negative regulation of fat cell differentiation GO:0045599 IMP
    histone H3 deacetylation GO:0070932 ISO
    autophagy GO:0006914 IEA
    cellular lipid catabolic process GO:0044242 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    myelination in peripheral nervous system GO:0022011 ISO
    negative regulation of striated muscle tissue development GO:0045843 ISO
    cell differentiation GO:0030154 IEA
    cellular response to caloric restriction GO:0061433 IDA
    regulation of cell cycle GO:0051726 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    regulation of myelination GO:0031641 ISO
    ripoptosome assembly involved in necroptotic process GO:1901026 IMP
    meiotic cell cycle GO:0051321 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia GO:2000777 ISO
    negative regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061428 ISO
    histone deacetylation GO:0016575 IGI
    cell cycle GO:0007049 IEA
    negative regulation of autophagy GO:0010507 ISO
    phosphatidylinositol 3-kinase signaling GO:0014065 ISO
    nervous system development GO:0007399 IEA
    regulation of fat cell differentiation GO:0045598 IMP
    hepatocyte growth factor receptor signaling pathway GO:0048012 ISO
    cellular response to molecule of bacterial origin GO:0071219 ISO
    negative regulation of protein catabolic process GO:0042177 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of oligodendrocyte differentiation GO:0048715 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of DNA binding GO:0043388 IDA
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of reactive oxygen species metabolic process GO:2000378 IMP
Subcellular Localization
    perikaryon GO:0043204 ISO
    chromosome GO:0005694 ISO
    terminal loop GO:0097456 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    midbody GO:0030496 ISO
    cell projection GO:0042995 IEA
    nuclear heterochromatin GO:0005720 ISO
    nucleus GO:0005634 ISO
    paranode region of axon GO:0033270 ISO
    plasma membrane GO:0005886 IEA
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
    centrosome GO:0005813 ISO
    juxtaparanode region of axon GO:0044224 ISO
    myelin sheath GO:0043209 ISO
    microtubule GO:0005874 ISO
    mitotic spindle GO:0072686 ISO
    Schmidt-Lanterman incisure GO:0043220 ISO
    centriole GO:0005814 ISO
    cytosol GO:0005829 ISO
    myelin sheath abaxonal region GO:0035748 ISO
    paranodal junction GO:0033010 ISO
    glial cell projection GO:0097386 ISO
    spindle GO:0005819 ISO
    meiotic spindle GO:0072687 IDA
    cytoskeleton GO:0005856 IEA
    lateral loop GO:0043219 ISO
 Experiment description of studies that identified Sirt2 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Sirt2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sirt2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here