Gene description for UBE2Q2
Gene name ubiquitin-conjugating enzyme E2Q family member 2
Gene symbol UBE2Q2
Other names/aliases -
Species Homo sapiens
 Database cross references - UBE2Q2
ExoCarta ExoCarta_92912
Entrez Gene 92912
HGNC 19248
MIM 612501
UniProt Q8WVN8  
 UBE2Q2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for UBE2Q2
Molecular Function
    ATP binding GO:0005524 IEA
    ligase activity GO:0016874 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
Biological Process
    protein K48-linked ubiquitination GO:0070936 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified UBE2Q2 in exosomes
1
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for UBE2Q2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBE2Q2 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome





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