Gene description for PECR
Gene name peroxisomal trans-2-enoyl-CoA reductase
Gene symbol PECR
Other names/aliases DCRRP
HPDHASE
HSA250303
PVIARL
SDR29C1
TERP
Species Homo sapiens
 Database cross references - PECR
ExoCarta ExoCarta_55825
Vesiclepedia VP_55825
Entrez Gene 55825
HGNC 18281
MIM 605843
UniProt Q9BY49  
 PECR identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PECR
Molecular Function
    signaling receptor binding GO:0005102 IPI
    2,4-dienoyl-CoA reductase (NADPH) activity GO:0008670 IDA
    trans-2-enoyl-CoA reductase (NADPH) activity GO:0019166 IBA
    trans-2-enoyl-CoA reductase (NADPH) activity GO:0019166 IDA
Biological Process
    fatty acid biosynthetic process GO:0006633 IEA
    phytol metabolic process GO:0033306 IBA
    phytol metabolic process GO:0033306 IDA
Subcellular Localization
    mitochondrion GO:0005739 IEA
    peroxisome GO:0005777 IBA
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 ISS
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PECR in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PECR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDPF1  
Affinity Capture-MS Homo sapiens
2 POMGNT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZUFSP 221302
Affinity Capture-MS Homo sapiens
4 UBE2E3 10477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PEX5 5830
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
6 TRIB1 10221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ACY1 95
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 C20orf195  
Affinity Capture-MS Homo sapiens
9 ISL1  
Reconstituted Complex Homo sapiens
10 LCN1 3933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 ACTA2 59
Affinity Capture-MS Homo sapiens
12 HNRNPF 3185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 UBA5 79876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TP53 7157
Affinity Capture-MS Homo sapiens
15 GRAP2 9402
Affinity Capture-MS Homo sapiens
16 RNF181  
Affinity Capture-MS Homo sapiens
17 RAP2A 5911
Affinity Capture-MS Homo sapiens
18 CPE 1363
Affinity Capture-MS Homo sapiens
19 HENMT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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