Gene description for Hsp90aa1
Gene name heat shock protein 90, alpha (cytosolic), class A member 1
Gene symbol Hsp90aa1
Other names/aliases 86kDa
89kDa
AL024080
AL024147
Hsp86-1
Hsp89
Hsp90
Hspca
hsp4
Species Mus musculus
 Database cross references - Hsp90aa1
ExoCarta ExoCarta_15519
Vesiclepedia VP_15519
Entrez Gene 15519
UniProt P07901  
 Hsp90aa1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Embryonic fibroblasts 18494037    
Fibroblasts 23260141    
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
Mast cells 17486113    
Microglia 16081791    
Neural stem cells 25242146    
Oligodendrocytes 21136642    
Pancreatic cells 19351151    
Plasma 33199621    
Plasma 33199621    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hsp90aa1
Molecular Function
    UTP binding GO:0002134 IEA
    UTP binding GO:0002134 ISO
    CTP binding GO:0002135 IEA
    CTP binding GO:0002135 ISO
    mRNA binding GO:0003729 IEA
    mRNA binding GO:0003729 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 ISO
    ATP binding GO:0005524 ISS
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 ISO
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IEA
    ATP hydrolysis activity GO:0016887 ISO
    sulfonylurea receptor binding GO:0017098 IEA
    sulfonylurea receptor binding GO:0017098 ISO
    protein phosphatase binding GO:0019903 IEA
    protein phosphatase binding GO:0019903 ISO
    nitric-oxide synthase regulator activity GO:0030235 IDA
    nitric-oxide synthase regulator activity GO:0030235 ISO
    TPR domain binding GO:0030911 ISO
    TPR domain binding GO:0030911 ISS
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    dATP binding GO:0032564 IEA
    dATP binding GO:0032564 ISO
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    histone deacetylase binding GO:0042826 IEA
    histone deacetylase binding GO:0042826 ISO
    protein folding chaperone GO:0044183 IMP
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 ISO
    tau protein binding GO:0048156 IEA
    tau protein binding GO:0048156 ISO
    GTPase binding GO:0051020 IEA
    GTPase binding GO:0051020 ISO
    Rho GDP-dissociation inhibitor binding GO:0051022 IEA
    Rho GDP-dissociation inhibitor binding GO:0051022 ISO
    unfolded protein binding GO:0051082 IBA
    unfolded protein binding GO:0051082 TAS
    DNA polymerase binding GO:0070182 IEA
    DNA polymerase binding GO:0070182 ISO
    scaffold protein binding GO:0097110 IEA
    scaffold protein binding GO:0097110 ISO
    disordered domain specific binding GO:0097718 IEA
    disordered domain specific binding GO:0097718 ISO
    ATP-dependent protein folding chaperone GO:0140662 IEA
    protein tyrosine kinase binding GO:1990782 IEA
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    neuron migration GO:0001764 IEA
    neuron migration GO:0001764 ISO
    positive regulation of protein phosphorylation GO:0001934 ISO
    activation of innate immune response GO:0002218 ISO
    activation of innate immune response GO:0002218 ISS
    positive regulation of defense response to virus by host GO:0002230 ISO
    positive regulation of defense response to virus by host GO:0002230 ISS
    skeletal muscle contraction GO:0003009 IEA
    protein folding GO:0006457 IBA
    protein folding GO:0006457 IMP
    nitric oxide biosynthetic process GO:0006809 TAS
    response to unfolded protein GO:0006986 TAS
    telomere maintenance via telomerase GO:0007004 IEA
    telomere maintenance via telomerase GO:0007004 ISO
    response to heat GO:0009408 ISS
    response to cold GO:0009409 ISS
    response to xenobiotic stimulus GO:0009410 IEA
    response to salt stress GO:0009651 IEA
    positive regulation of lamellipodium assembly GO:0010592 IEA
    positive regulation of lamellipodium assembly GO:0010592 ISO
    cardiac muscle cell apoptotic process GO:0010659 IEA
    regulation of protein ubiquitination GO:0031396 IEA
    regulation of protein ubiquitination GO:0031396 ISO
    positive regulation of protein polymerization GO:0032273 IEA
    positive regulation of protein polymerization GO:0032273 ISO
    positive regulation of interferon-beta production GO:0032728 ISO
    positive regulation of interferon-beta production GO:0032728 ISS
    regulation of protein localization GO:0032880 IMP
    cellular response to heat GO:0034605 IBA
    cellular response to heat GO:0034605 IMP
    protein refolding GO:0042026 TAS
    response to cocaine GO:0042220 IEA
    positive regulation of protein import into nucleus GO:0042307 IEA
    positive regulation of protein import into nucleus GO:0042307 ISO
    regulation of apoptotic process GO:0042981 ISO
    regulation of apoptotic process GO:0042981 ISS
    response to estrogen GO:0043627 IEA
    protein insertion into mitochondrial outer membrane GO:0045040 IEA
    protein insertion into mitochondrial outer membrane GO:0045040 ISO
    positive regulation of nitric oxide biosynthetic process GO:0045429 IDA
    positive regulation of cytotoxic T cell differentiation GO:0045585 TAS
    positive regulation of protein catabolic process GO:0045732 IEA
    positive regulation of protein catabolic process GO:0045732 ISO
    positive regulation of cell size GO:0045793 IEA
    positive regulation of cell size GO:0045793 ISO
    response to antibiotic GO:0046677 ISS
    protein stabilization GO:0050821 IBA
    protein stabilization GO:0050821 IEA
    protein stabilization GO:0050821 ISO
    chaperone-mediated protein complex assembly GO:0051131 IEA
    chaperone-mediated protein complex assembly GO:0051131 ISO
    positive regulation of cardiac muscle contraction GO:0060452 IEA
    cellular response to virus GO:0098586 ISO
    cellular response to virus GO:0098586 ISS
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 ISO
    positive regulation of tau-protein kinase activity GO:1902949 ISO
    neurofibrillary tangle assembly GO:1902988 IEA
    telomerase holoenzyme complex assembly GO:1905323 IEA
    telomerase holoenzyme complex assembly GO:1905323 ISO
Subcellular Localization
    intracellular anatomical structure GO:0005622 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    brush border membrane GO:0031526 IEA
    brush border membrane GO:0031526 ISO
    protein-containing complex GO:0032991 IBA
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 ISO
    sperm flagellum GO:0036126 ISO
    melanosome GO:0042470 IEA
    neuronal cell body GO:0043025 IBA
    neuronal cell body GO:0043025 IDA
    neuronal cell body GO:0043025 ISO
    myelin sheath GO:0043209 HDA
    myelin sheath GO:0043209 IBA
    myelin sheath GO:0043209 ISO
    dendritic growth cone GO:0044294 IDA
    axonal growth cone GO:0044295 IDA
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    collagen-containing extracellular matrix GO:0062023 IEA
    collagen-containing extracellular matrix GO:0062023 ISO
    sperm mitochondrial sheath GO:0097226 IEA
    sperm mitochondrial sheath GO:0097226 ISO
    sperm plasma membrane GO:0097524 IEA
    sperm plasma membrane GO:0097524 ISO
 Experiment description of studies that identified Hsp90aa1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 73
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors "Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ"
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
3
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
8
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
9
Experiment ID 14
MISEV standards
✔
EM
Biophysical techniques
✔
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
Enriched markers
✔
DNM
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors "Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L"
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
10
Experiment ID 264
MISEV standards
✘ Biophysical techniques
✔
CD63|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 33
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
12
Experiment ID 188
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|UCHL1|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 315
MISEV standards
✘ Biophysical techniques
✔
Cd63|Cd9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 33199621    
Organism Mus musculus
Experiment description Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice
Authors "Castaño C, Mirasierra M, Vallejo M, Novials A, Párrizas M."
Journal name Proc Natl Acad Sci U S A
Publication year 2020
Sample Plasma
Sample name Plasma - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
RT-PCT
14
Experiment ID 316
MISEV standards
✔
EM
Biophysical techniques
✔
Cd63|Cd9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 33199621    
Organism Mus musculus
Experiment description Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice
Authors "Castaño C, Mirasierra M, Vallejo M, Novials A, Párrizas M."
Journal name Proc Natl Acad Sci U S A
Publication year 2020
Sample Plasma
Sample name Plasma - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
RT-PCT
15
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hsp90aa1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Krt8 16691
Affinity Capture-Western Mus musculus
3 Chordc1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
4 Akt1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
5 Tmem173  
Proximity Label-MS Mus musculus
6 Nr3c1  
Affinity Capture-Western Mus musculus
7 Hif1a  
Affinity Capture-Western Mus musculus
8 Kpnb1 16211
Affinity Capture-Western Mus musculus
9 Itgb1bp2  
Reconstituted Complex Mus musculus
10 HTT 3064
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
11 QKI 9444
Two-hybrid Homo sapiens
12 Rpl6 19988
Co-fractionation Mus musculus
13 Cdk4  
Co-fractionation Mus musculus
Reconstituted Complex Mus musculus
14 Tfe3  
Affinity Capture-MS Mus musculus
15 Iqcb1  
Affinity Capture-MS Mus musculus
16 Lrrk2  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
17 Prkcd  
Affinity Capture-Western Mus musculus
18 Fkbp4 14228
Two-hybrid Mus musculus
19 Ywhae 22627
Co-fractionation Mus musculus
20 Stip1 20867
Co-fractionation Mus musculus
21 Ywhaq 22630
Co-fractionation Mus musculus
22 Nphp4  
Affinity Capture-MS Mus musculus
23 Nod1  
Affinity Capture-Western Mus musculus
24 Traf6  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
25 MAPT  
Reconstituted Complex Homo sapiens
26 Ywhab 54401
Co-fractionation Mus musculus
27 Nup62  
Affinity Capture-Western Mus musculus
28 Cdc37 12539
Affinity Capture-Western Mus musculus
29 Unk  
Affinity Capture-RNA Mus musculus
30 Tsc1  
Affinity Capture-MS Mus musculus
31 Rpl30 19946
Co-fractionation Mus musculus
32 Eed  
Affinity Capture-MS Mus musculus
33 Ywhaz 22631
Co-fractionation Mus musculus
34 Rnf114  
Co-fractionation Mus musculus
35 Ahi1  
Affinity Capture-MS Mus musculus
36 Atg16l1  
Affinity Capture-MS Mus musculus
37 Nphp1  
Affinity Capture-MS Mus musculus
38 STIP1 10963
Two-hybrid Homo sapiens
39 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hsp90aa1 is involved
PathwayEvidenceSource
Anchoring of the basal body to the plasma membrane IEA Reactome
Attenuation phase IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Axon guidance IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular response to heat stress IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Centrosome maturation IEA Reactome
Cilium Assembly IEA Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Developmental Biology IEA Reactome
Downregulation of ERBB2 signaling IEA Reactome
Drug-mediated inhibition of ERBB2 signaling IEA Reactome
eNOS activation IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
Extra-nuclear estrogen signaling IEA Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
G2/M Transition IEA Reactome
HSF1 activation IEA Reactome
HSF1-dependent transactivation IEA Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
Metabolism IEA Reactome
Metabolism of cofactors IEA Reactome
Metabolism of nitric oxide: NOS3 activation and regulation IEA Reactome
Metabolism of vitamins and cofactors IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Prometaphase IEA Reactome
Nervous system development IEA Reactome
Neutrophil degranulation IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
Programmed Cell Death IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulated Necrosis IEA Reactome
Regulation of actin dynamics for phagocytic cup formation IEA Reactome
Regulation of necroptotic cell death IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
RHO GTPase cycle IEA Reactome
RHOBTB GTPase Cycle IEA Reactome
RHOBTB2 GTPase cycle IEA Reactome
RIPK1-mediated regulated necrosis IEA Reactome
Sema3A PAK dependent Axon repulsion IEA Reactome
Semaphorin interactions IEA Reactome
Signal Transduction IEA Reactome
Signaling by ERBB2 IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by VEGF IEA Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation IEA Reactome
The role of GTSE1 in G2/M progression after G2 checkpoint IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated vascular permeability IEA Reactome





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