Gene description for Krt8
Gene name keratin 8
Gene symbol Krt8
Other names/aliases AA960620
AL022697
AU019895
Card2
EndoA
K8
Krt-2.8
Krt2-8
Species Mus musculus
 Database cross references - Krt8
ExoCarta ExoCarta_16691
Entrez Gene 16691
UniProt P11679  
 Krt8 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt8
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein complex binding GO:0032403 ISO
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 ISO
Biological Process
    cell differentiation involved in embryonic placenta development GO:0060706 IGI
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    response to other organism GO:0051707 IMP
    response to hydrostatic pressure GO:0051599 ISO
    sarcomere organization GO:0045214 ISO
    hepatocyte apoptotic process GO:0097284 IMP
    multicellular organismal development GO:0007275 TAS
    cell morphogenesis involved in differentiation GO:0000904 TAS
    tumor necrosis factor-mediated signaling pathway GO:0033209 IMP
Subcellular Localization
    Z disc GO:0030018 ISO
    keratin filament GO:0045095 ISO
    cell-cell junction GO:0005911 IDA
    extracellular exosome GO:0070062 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    cell periphery GO:0071944 IDA
    costamere GO:0043034 ISO
    cytoplasm GO:0005737 ISO
    sarcolemma GO:0042383 ISO
    dystrophin-associated glycoprotein complex GO:0016010 ISO
    nucleus GO:0005634 ISO
    intermediate filament GO:0005882 ISO
 Experiment description of studies that identified Krt8 in exosomes
1
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt8 is involved
No pathways found





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