Gene description for Dsp
Gene name desmoplakin
Gene symbol Dsp
Other names/aliases 2300002E22Rik
5730453H04Rik
AA407887
AA407888
AW109828
DP
rul
Species Mus musculus
 Database cross references - Dsp
ExoCarta ExoCarta_109620
Vesiclepedia VP_109620
Entrez Gene 109620
UniProt E9Q557  
 Dsp identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dsp
Molecular Function
    protein kinase C binding GO:0005080 IEA
    protein kinase C binding GO:0005080 ISO
    structural molecule activity GO:0005198 IBA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 IEA
    scaffold protein binding GO:0097110 ISO
Biological Process
    desmosome organization GO:0002934 IMP
    desmosome organization GO:0002934 IMP
    ventricular compact myocardium morphogenesis GO:0003223 IMP
    peptide cross-linking GO:0018149 ISO
    keratinocyte differentiation GO:0030216 IEA
    keratinocyte differentiation GO:0030216 ISO
    adherens junction organization GO:0034332 IMP
    wound healing GO:0042060 IBA
    skin development GO:0043588 IBA
    skin development GO:0043588 IMP
    intermediate filament cytoskeleton organization GO:0045104 IBA
    intermediate filament cytoskeleton organization GO:0045104 IMP
    intermediate filament organization GO:0045109 IMP
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 IEA
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 ISO
    regulation of heart rate by cardiac conduction GO:0086091 IEA
    regulation of heart rate by cardiac conduction GO:0086091 ISO
    epithelial cell-cell adhesion GO:0090136 ISO
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IMP
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IEA
    regulation of ventricular cardiac muscle cell action potential GO:0098911 ISO
    protein localization to cell-cell junction GO:0150105 IMP
Subcellular Localization
    cornified envelope GO:0001533 IEA
    cornified envelope GO:0001533 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    intermediate filament GO:0005882 IBA
    intermediate filament GO:0005882 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 IDA
    adherens junction GO:0005912 IDA
    fascia adherens GO:0005916 IEA
    fascia adherens GO:0005916 ISO
    intercalated disc GO:0014704 IBA
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISO
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IDA
    desmosome GO:0030057 IDA
    desmosome GO:0030057 ISO
 Experiment description of studies that identified Dsp in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dsp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Eed  
Affinity Capture-MS Mus musculus
2 Krt8 16691
Co-fractionation Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Dsp 109620
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
6 Sox17  
Affinity Capture-MS Mus musculus
7 Tfe3  
Affinity Capture-MS Mus musculus
8 MTNR1B  
Reconstituted Complex Homo sapiens
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