Gene description for Krt18
Gene name keratin 18
Gene symbol Krt18
Other names/aliases CK18
K18
Krt1-18
Species Mus musculus
 Database cross references - Krt18
ExoCarta ExoCarta_16668
Vesiclepedia VP_16668
Entrez Gene 16668
UniProt P05784  
 Krt18 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt18
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 IEA
    scaffold protein binding GO:0097110 ISO
Biological Process
    tumor necrosis factor-mediated signaling pathway GO:0033209 IGI
    Golgi to plasma membrane protein transport GO:0043001 IEA
    Golgi to plasma membrane protein transport GO:0043001 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    intermediate filament cytoskeleton organization GO:0045104 IBA
    intermediate filament cytoskeleton organization GO:0045104 IEA
    intermediate filament cytoskeleton organization GO:0045104 ISO
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    hepatocyte apoptotic process GO:0097284 IMP
Subcellular Localization
    extracellular space GO:0005615 ISO
    nucleolus GO:0005730 IEA
    cytoplasm GO:0005737 ISO
    microtubule organizing center GO:0005815 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IDA
    intermediate filament GO:0005882 ISO
    external side of plasma membrane GO:0009897 ISO
    nuclear matrix GO:0016363 IEA
    protein-containing complex GO:0032991 ISO
    centriolar satellite GO:0034451 IEA
    centriolar satellite GO:0034451 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    keratin filament GO:0045095 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Krt18 in exosomes
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Krt72  
Co-fractionation Mus musculus
2 Krt8 16691
Co-fractionation Mus musculus
3 Tango6  
Co-fractionation Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Ush2a  
Co-fractionation Mus musculus
6 Pkp1  
Co-fractionation Mus musculus
7 Fkbp3  
Co-fractionation Mus musculus
8 Pkp3  
Co-fractionation Mus musculus
9 Rtcb 28088
Co-fractionation Mus musculus
10 2700060E02Rik 68045
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Krt18 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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