Gene description for Krt18
Gene name keratin 18
Gene symbol Krt18
Other names/aliases CK18
Species Mus musculus
 Database cross references - Krt18
ExoCarta ExoCarta_16668
Entrez Gene 16668
UniProt P05784  
 Krt18 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt18
Molecular Function
    protein binding GO:0005515 IPI
    scaffold protein binding GO:0097110 ISO
    structural molecule activity GO:0005198 IEA
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    Golgi to plasma membrane CFTR protein transport GO:0043000 ISO
    hepatocyte apoptotic process GO:0097284 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    intermediate filament cytoskeleton organization GO:0045104 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 IGI
    extrinsic apoptotic signaling pathway GO:0097191 IMP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    intermediate filament GO:0005882 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IEA
    centriolar satellite GO:0034451 ISO
    cell periphery GO:0071944 IDA
    microtubule organizing center GO:0005815 ISO
    keratin filament GO:0045095 ISO
 Experiment description of studies that identified Krt18 in exosomes
Experiment ID 33
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt18 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here