Gene description for Zdhhc5
Gene name zinc finger, DHHC domain containing 5
Gene symbol Zdhhc5
Other names/aliases 1110032A17Rik
AI451382
Zisp
Species Mus musculus
 Database cross references - Zdhhc5
ExoCarta ExoCarta_228136
Vesiclepedia VP_228136
Entrez Gene 228136
UniProt Q8VDZ4  
 Zdhhc5 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Zdhhc5
Molecular Function
    protein binding GO:0005515 IPI
    palmitoyltransferase activity GO:0016409 IBA
    palmitoyltransferase activity GO:0016409 IDA
    palmitoyltransferase activity GO:0016409 ISO
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISO
    protein-cysteine S-palmitoyltransferase activity GO:0019706 ISS
Biological Process
    lipid transport GO:0006869 IEA
    protein palmitoylation GO:0018345 IDA
    protein palmitoylation GO:0018345 IMP
    protein palmitoylation GO:0018345 ISO
    innate immune response GO:0045087 IEA
    positive regulation of pattern recognition receptor signaling pathway GO:0062208 IBA
    positive regulation of pattern recognition receptor signaling pathway GO:0062208 IMP
    positive regulation of pattern recognition receptor signaling pathway GO:0062208 ISO
    protein localization to plasma membrane GO:0072659 IEA
    protein localization to plasma membrane GO:0072659 ISO
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 ISO
    positive regulation of pyroptotic inflammatory response GO:0140639 IMP
    positive regulation of pyroptotic inflammatory response GO:0140639 ISS
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IEA
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 IMP
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
    positive regulation of protein localization to phagocytic vesicle GO:1905171 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISO
    phagocytic vesicle GO:0045335 IDA
    phagocytic vesicle GO:0045335 ISO
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 ISO
    GABA-ergic synapse GO:0098982 IEA
    GABA-ergic synapse GO:0098982 ISO
    postsynaptic specialization, intracellular component GO:0099091 IEA
    postsynaptic specialization, intracellular component GO:0099091 ISO
 Experiment description of studies that identified Zdhhc5 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Zdhhc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
2 Krt8 16691
Co-fractionation Mus musculus
3 Myo6  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zdhhc5 is involved
No pathways found





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