Gene description for DIS3L2
Gene name DIS3 like 3'-5' exoribonuclease 2
Gene symbol DIS3L2
Other names/aliases FAM6A
Species Homo sapiens
 Database cross references - DIS3L2
ExoCarta ExoCarta_129563
Entrez Gene 129563
HGNC 28648
MIM 614184
UniProt Q8IYB7  
 DIS3L2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DIS3L2
Molecular Function
    3'-5'-exoribonuclease activity GO:0000175 IDA
    protein binding GO:0005515 IPI
    ribonuclease activity GO:0004540 IDA
    magnesium ion binding GO:0000287 IDA
    poly(U) RNA binding GO:0008266 IDA
Biological Process
    rRNA catabolic process GO:0016075 IBA
    mitotic sister chromatid separation GO:0051306 IMP
    RNA phosphodiester bond hydrolysis GO:0090501 IDA
    nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' GO:0034427 IEA
    polyuridylation-dependent mRNA catabolic process GO:1990074 ISS
    mitotic nuclear division GO:0007067 IMP
    negative regulation of cell proliferation GO:0008285 IMP
    miRNA catabolic process GO:0010587 ISS
    nuclear-transcribed mRNA catabolic process, exonucleolytic GO:0000291 IMP
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 IEA
    rRNA processing GO:0006364 IBA
    cell division GO:0051301 IEA
    stem cell maintenance GO:0019827 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nuclear exosome (RNase complex) GO:0000176 IBA
    cytoplasmic exosome (RNase complex) GO:0000177 IBA
    polysome GO:0005844 TAS
    cytoplasmic mRNA processing body GO:0000932 IDA
 Experiment description of studies that identified DIS3L2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DIS3L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VIM 7431
Two-hybrid Homo sapiens
2 VCL 7414
Affinity Capture-MS Homo sapiens
3 COPS6 10980
Two-hybrid Homo sapiens
4 FEZ1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DIS3L2 is involved
No pathways found

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