Gene description for GCNT3
Gene name glucosaminyl (N-acetyl) transferase 3, mucin type
Gene symbol GCNT3
Other names/aliases C2/4GnT
C24GNT
C2GNT2
C2GNTM
GNTM
Species Homo sapiens
 Database cross references - GCNT3
ExoCarta ExoCarta_9245
Entrez Gene 9245
HGNC 4205
MIM 606836
UniProt O95395  
 GCNT3 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for GCNT3
Molecular Function
    N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity GO:0008109 IEA
    beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity GO:0003829 IEA
    acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity GO:0047225 IEA
Biological Process
    protein O-linked glycosylation GO:0006493 TAS
    carbohydrate metabolic process GO:0005975 NAS
    kidney morphogenesis GO:0060993 IEA
    intestinal absorption GO:0050892 IEA
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    tissue morphogenesis GO:0048729 IEA
    O-glycan processing GO:0016266 TAS
    immunoglobulin production in mucosal tissue GO:0002426 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 TAS
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified GCNT3 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for GCNT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GCNT3 is involved
PathwayEvidenceSource
O-linked glycosylation of mucins TAS Reactome





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