Gene description for PPIC
Gene name peptidylprolyl isomerase C (cyclophilin C)
Gene symbol PPIC
Other names/aliases CYPC
Species Homo sapiens
 Database cross references - PPIC
ExoCarta ExoCarta_5480
Entrez Gene 5480
HGNC 9256
MIM 123842
UniProt P45877  
 PPIC identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PPIC
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    protein binding GO:0005515 IPI
    cyclosporin A binding GO:0016018 IDA
Biological Process
    protein peptidyl-prolyl isomerization GO:0000413 IBA
    protein folding GO:0006457 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified PPIC in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PPIC
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPIC is involved
No pathways found





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