Gene description for GPX3
Gene name glutathione peroxidase 3
Gene symbol GPX3
Other names/aliases GPx-P
GSHPx-3
GSHPx-P
Species Homo sapiens
 Database cross references - GPX3
ExoCarta ExoCarta_2878
Entrez Gene 2878
HGNC 4555
MIM 138321
UniProt P22352  
 GPX3 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for GPX3
Molecular Function
    glutathione peroxidase activity GO:0004602 IDA
    protein binding GO:0005515 IPI
    selenium binding GO:0008430 IDA
    transcription factor binding GO:0008134 TAS
Biological Process
    hydrogen peroxide catabolic process GO:0042744 TAS
    protein homotetramerization GO:0051289 IDA
    oxidation-reduction process GO:0055114 IEA
    response to reactive oxygen species GO:0000302 TAS
    response to lipid hydroperoxide GO:0006982 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified GPX3 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for GPX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GPX3 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species TAS Reactome





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