Gene description for GABRB2
Gene name gamma-aminobutyric acid (GABA) A receptor, beta 2
Gene symbol GABRB2
Other names/aliases -
Species Homo sapiens
 Database cross references - GABRB2
ExoCarta ExoCarta_2561
Vesiclepedia VP_2561
Entrez Gene 2561
HGNC 4082
MIM 600232
UniProt P47870  
 GABRB2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GABRB2
Molecular Function
    GABA-A receptor activity GO:0004890 ISS
    chloride channel activity GO:0005254 ISS
    inhibitory extracellular ligand-gated ion channel activity GO:0005237 IEA
Biological Process
    synaptic transmission GO:0007268 TAS
    inner ear receptor cell development GO:0060119 IEA
    cellular response to histamine GO:0071420 ISS
    synaptic transmission, GABAergic GO:0051932 ISS
    chloride transmembrane transport GO:1902476 ISS
    cochlea development GO:0090102 IEA
    innervation GO:0060384 IEA
    ion transmembrane transport GO:0034220 TAS
    sensory perception of sound GO:0007605 IEA
    transmembrane transport GO:0055085 TAS
    transport GO:0006810 TAS
    gamma-aminobutyric acid signaling pathway GO:0007214 TAS
    negative regulation of neuron apoptotic process GO:0043524 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
    GABA-A receptor complex GO:1902711 ISS
    postsynaptic membrane GO:0045211 IEA
    integral component of plasma membrane GO:0005887 ISS
    cell junction GO:0030054 IEA
    plasma membrane GO:0005886 TAS
    chloride channel complex GO:0034707 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GABRB2 in exosomes
1
Experiment ID 63
MISEV standards
✘ EV Biophysical techniques
✔
AQP2
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GABRB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAK2 66008
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GABRB2 is involved
PathwayEvidenceSource
GABA A receptor activation TAS Reactome
Ligand-gated ion channel transport TAS Reactome





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