Gene description for SLPI
Gene name secretory leukocyte peptidase inhibitor
Gene symbol SLPI
Other names/aliases ALK1
ALP
BLPI
HUSI
HUSI-I
MPI
WAP4
WFDC4
Species Homo sapiens
 Database cross references - SLPI
ExoCarta ExoCarta_6590
Vesiclepedia VP_6590
Entrez Gene 6590
HGNC 11092
MIM 107285
UniProt P03973  
 SLPI identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for SLPI
Molecular Function
    enzyme binding GO:0019899 IPI
    endopeptidase inhibitor activity GO:0004866 TAS
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IEA
    negative regulation of viral genome replication GO:0045071 IDA
    negative regulation of protein binding GO:0032091 IDA
Subcellular Localization
    extracellular matrix GO:0031012 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLPI in exosomes
1
Experiment ID 66
MISEV standards
IEM
EV Biophysical techniques
TSG101|Alix|CD63|CD81
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SLPI
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLSCR1 5359
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 ELANE 1991
Invitro Homo sapiens
3 PRSS2 5645
Invitro Homo sapiens
4 GRN 2896
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SLPI is involved
No pathways found





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