Gene description for IGLC1
Gene name immunoglobulin lambda constant 1 (Mcg marker)
Gene symbol IGLC1
Other names/aliases IGLC
Species Homo sapiens
 Database cross references - IGLC1
ExoCarta ExoCarta_3537
Vesiclepedia VP_3537
Entrez Gene 3537
HGNC 5855
MIM 147220
 IGLC1 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
Mesenchymal stem cells Unpublished / Not applicable
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for IGLC1
Molecular Function
    antigen binding GO:0003823 IBA
    antigen binding GO:0003823 NAS
Biological Process
    adaptive immune response GO:0002250 NAS
    immune response GO:0006955 NAS
    immunoglobulin mediated immune response GO:0016064 IBA
    B cell receptor signaling pathway GO:0050853 NAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 NAS
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 HDA
    IgG immunoglobulin complex GO:0071735 IBA
    IgG immunoglobulin complex GO:0071735 NAS
    IgD immunoglobulin complex GO:0071738 NAS
    IgE immunoglobulin complex GO:0071742 NAS
    IgA immunoglobulin complex GO:0071745 NAS
    IgM immunoglobulin complex GO:0071753 NAS
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified IGLC1 in exosomes
1
Experiment ID 46
MISEV standards
EM|IEM
Biophysical techniques
HSC70|CD63|MHCII|CD81|CD86
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Colostrum
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
2
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
3
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IGLC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SERPINA1 5265
Affinity Capture-MS Homo sapiens
2 HBB 3043
Affinity Capture-MS Homo sapiens
3 UBQLN4 56893
Two-hybrid Homo sapiens
4 STATH  
Affinity Capture-MS Homo sapiens
5 DCD 117159
Affinity Capture-MS Homo sapiens
6 WWOX 51741
Affinity Capture-MS Homo sapiens
7 NTPCR 84284
Affinity Capture-MS Homo sapiens
8 FOXO1  
Affinity Capture-MS Homo sapiens
9 WHSC1 7468
Affinity Capture-MS Homo sapiens
10 PMM2 5373
Affinity Capture-MS Homo sapiens
11 COL1A1 1277
Affinity Capture-MS Homo sapiens
12 HCCS 3052
Affinity Capture-MS Homo sapiens
13 HP 3240
Affinity Capture-MS Homo sapiens
14 HR  
Affinity Capture-MS Homo sapiens
15 PHF23 79142
Affinity Capture-MS Homo sapiens
16 PRR4 11272
Affinity Capture-MS Homo sapiens
17 CUL7 9820
Affinity Capture-MS Homo sapiens
18 LCN1 3933
Affinity Capture-MS Homo sapiens
19 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 PAX3  
Affinity Capture-MS Homo sapiens
22 L3MBTL4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGLC1 is involved
No pathways found





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