Gene description for PLA2G16
Gene name phospholipase A2, group XVI
Gene symbol PLA2G16
Other names/aliases AdPLA
H-REV107-1
HRASLS3
HREV107
HREV107-1
HREV107-3
HRSL3
Species Homo sapiens
 Database cross references - PLA2G16
ExoCarta ExoCarta_11145
Entrez Gene 11145
HGNC 17825
MIM 613867
UniProt P53816  
 PLA2G16 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PLA2G16
Molecular Function
    phospholipase A2 activity GO:0004623 IDA
    protein binding GO:0005515 IPI
    1-acyl-2-lysophosphatidylserine acylhydrolase activity GO:0052740 IEA
    phosphatidylserine 1-acylhydrolase activity GO:0052739 IEA
    phosphatidylcholine 1-acylhydrolase activity GO:0008970 IEA
Biological Process
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylcholine acyl-chain remodeling GO:0036151 TAS
    negative regulation of cell cycle GO:0045786 IEA
    phosphatidylserine acyl-chain remodeling GO:0036150 TAS
    phosphatidylethanolamine acyl-chain remodeling GO:0036152 TAS
    phosphatidylinositol acyl-chain remodeling GO:0036149 TAS
    glycerophospholipid biosynthetic process GO:0046474 TAS
    lipid catabolic process GO:0016042 IEA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    cellular_component GO:0005575 ND
    endoplasmic reticulum GO:0005783 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PLA2G16 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PLA2G16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBQLN1 29979
Two-hybrid Homo sapiens
View the network image/svg+xml



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