Gene description for MBL2
Gene name mannose-binding lectin (protein C) 2, soluble
Gene symbol MBL2
Other names/aliases COLEC1
Species Homo sapiens
 Database cross references - MBL2
ExoCarta ExoCarta_4153
Entrez Gene 4153
HGNC 6922
MIM 154545
UniProt P11226  
 MBL2 identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for MBL2
Molecular Function
    mannose binding GO:0005537 TAS
    receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    calcium-dependent protein binding GO:0048306 IPI
    calcium ion binding GO:0005509 IBA
Biological Process
    opsonization GO:0008228 TAS
    complement activation, classical pathway GO:0006958 IEA
    killing by host of symbiont cells GO:0051873 IEA
    complement activation, lectin pathway GO:0001867 TAS
    acute-phase response GO:0006953 TAS
    positive regulation of phagocytosis GO:0050766 IEA
    defense response to bacterium GO:0042742 TAS
    negative regulation of growth of symbiont in host GO:0044130 IDA
    innate immune response GO:0045087 TAS
    defense response to Gram-positive bacterium GO:0050830 IDA
    response to oxidative stress GO:0006979 NAS
    negative regulation of viral process GO:0048525 IDA
    complement activation GO:0006956 TAS
Subcellular Localization
    cell surface GO:0009986 TAS
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified MBL2 in exosomes
Experiment ID 44
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for MBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MASP2 10747
Affinity Capture-Western Homo sapiens
2 CALR 811
Reconstituted Complex Homo sapiens
3 MBL2 4153
Invitro Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 KRT1 3848
Affinity Capture-Western Homo sapiens
6 C1QR1  
Invitro Homo sapiens
7 MASP1 5648
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MBL2 is involved
Initial triggering of complement TAS Reactome
Lectin pathway of complement activation TAS Reactome

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