Gene description for EIF4EBP2
Gene name eukaryotic translation initiation factor 4E binding protein 2
Gene symbol EIF4EBP2
Other names/aliases 4EBP2
PHASII
Species Homo sapiens
 Database cross references - EIF4EBP2
ExoCarta ExoCarta_1979
Entrez Gene 1979
HGNC 3289
MIM 602224
UniProt Q13542  
 EIF4EBP2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for EIF4EBP2
Molecular Function
    eukaryotic initiation factor 4E binding GO:0008190 ISS
    protein binding GO:0005515 IPI
    translation repressor activity GO:0030371 ISS
Biological Process
    memory GO:0007613 ISS
    cAMP-mediated signaling GO:0019933 IEA
    TOR signaling GO:0031929 ISS
    negative regulation of translational initiation GO:0045947 ISS
    social behavior GO:0035176 ISS
    regulation of synaptic plasticity GO:0048167 ISS
    translation GO:0006412 TAS
    regulation of synaptic transmission GO:0050804 ISS
    insulin receptor signaling pathway GO:0008286 IEA
Subcellular Localization
    intracellular GO:0005622 ISS
 Experiment description of studies that identified EIF4EBP2 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for EIF4EBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4E 1977
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which EIF4EBP2 is involved
No pathways found





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