Gene description for EIF4EBP2
Gene name eukaryotic translation initiation factor 4E binding protein 2
Gene symbol EIF4EBP2
Other names/aliases 4EBP2
PHASII
Species Homo sapiens
 Database cross references - EIF4EBP2
ExoCarta ExoCarta_1979
Vesiclepedia VP_1979
Entrez Gene 1979
HGNC 3289
MIM 602224
UniProt Q13542  
 EIF4EBP2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for EIF4EBP2
Molecular Function
    protein binding GO:0005515 IPI
    eukaryotic initiation factor 4E binding GO:0008190 IBA
    eukaryotic initiation factor 4E binding GO:0008190 ISS
    translation repressor activity GO:0030371 IDA
    translation repressor activity GO:0030371 ISS
Biological Process
    translation GO:0006412 TAS
    memory GO:0007613 ISS
    insulin receptor signaling pathway GO:0008286 IEA
    TOR signaling GO:0031929 ISS
    social behavior GO:0035176 ISS
    negative regulation of translational initiation GO:0045947 IBA
    negative regulation of translational initiation GO:0045947 IDA
    negative regulation of translational initiation GO:0045947 ISS
    regulation of synaptic plasticity GO:0048167 ISS
    modulation of chemical synaptic transmission GO:0050804 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    intracellular membraneless organelle GO:0043232 IDA
    neuronal ribonucleoprotein granule GO:0071598 IDA
    postsynapse GO:0098794 IEA
 Experiment description of studies that identified EIF4EBP2 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for EIF4EBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF4A2 1974
Affinity Capture-MS Homo sapiens
2 EIF4G3 8672
Affinity Capture-MS Homo sapiens
3 EIF3A 8661
Affinity Capture-MS Homo sapiens
4 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
5 ARHGAP17 55114
Co-fractionation Homo sapiens
6 EIF3G 8666
Affinity Capture-MS Homo sapiens
7 EIF3C 8663
Affinity Capture-MS Homo sapiens
8 EIF3K 27335
Affinity Capture-MS Homo sapiens
9 EIF3I 8668
Affinity Capture-MS Homo sapiens
10 RDH12 145226
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 HNRNPA2B1 3181
Co-fractionation Homo sapiens
12 RPTOR 57521
Affinity Capture-Western Homo sapiens
13 EIF4G1 1981
Affinity Capture-MS Homo sapiens
14 FHL3 2275
Two-hybrid Homo sapiens
15 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
16 EIF3F 8665
Affinity Capture-MS Homo sapiens
17 EIF4E 1977
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
18 EIF4E2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
20 TXN 7295
Co-fractionation Homo sapiens
21 LSM3 27258
Two-hybrid Homo sapiens
22 CDK4 1019
Two-hybrid Homo sapiens
23 MTOR 2475
Biochemical Activity Homo sapiens
24 EIF3B 8662
Affinity Capture-MS Homo sapiens
25 RPS27L 51065
Affinity Capture-MS Homo sapiens
26 EIF3M 10480
Affinity Capture-MS Homo sapiens
27 TBCA 6902
Co-fractionation Homo sapiens
28 NFYA 4800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 EIF4EBP1  
Affinity Capture-MS Homo sapiens
30 ANGEL1  
Affinity Capture-MS Homo sapiens
31 EIF3E 3646
Affinity Capture-MS Homo sapiens
32 EIF3D 8664
Affinity Capture-MS Homo sapiens
33 EIF3H 8667
Affinity Capture-MS Homo sapiens
34 EIF3L 51386
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EIF4EBP2 is involved
No pathways found





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