Gene description for AP4M1
Gene name adaptor-related protein complex 4, mu 1 subunit
Gene symbol AP4M1
Other names/aliases CPSQ3
MU-4
MU-ARP2
SPG50
Species Homo sapiens
 Database cross references - AP4M1
ExoCarta ExoCarta_9179
Entrez Gene 9179
HGNC 574
MIM 602296
UniProt O00189  
 AP4M1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for AP4M1
Molecular Function
    transporter activity GO:0005215 TAS
    protein binding GO:0005515 IPI
Biological Process
    vesicle-mediated transport GO:0016192 TAS
    post-Golgi vesicle-mediated transport GO:0006892 TAS
    Golgi to endosome transport GO:0006895 IMP
    membrane organization GO:0061024 TAS
    intracellular protein transport GO:0006886 IMP
Subcellular Localization
    AP-type membrane coat adaptor complex GO:0030119 TAS
    trans-Golgi network membrane GO:0032588 TAS
    coated pit GO:0005905 IEA
    Golgi trans cisterna GO:0000138 TAS
    endosome lumen GO:0031904 TAS
    extracellular exosome GO:0070062 IDA
    clathrin adaptor complex GO:0030131 IEA
    trans-Golgi network GO:0005802 IDA
 Experiment description of studies that identified AP4M1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for AP4M1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARF1 375
Two-hybrid Homo sapiens
2 CD63 967
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which AP4M1 is involved
PathwayEvidenceSource
Lysosome Vesicle Biogenesis TAS Reactome





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