Gene description for DISP1
Gene name dispatched homolog 1 (Drosophila)
Gene symbol DISP1
Other names/aliases DISPA
Species Homo sapiens
 Database cross references - DISP1
ExoCarta ExoCarta_84976
Entrez Gene 84976
HGNC 19711
MIM 607502
UniProt Q96F81  
 DISP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DISP1
Molecular Function
    peptide transporter activity GO:0015197 ISS
    protein binding GO:0005515 IPI
    hedgehog receptor activity GO:0008158 IEA
Biological Process
    diaphragm development GO:0060539 IMP
    dorsal/ventral pattern formation GO:0009953 IEA
    determination of left/right symmetry GO:0007368 IEA
    embryonic pattern specification GO:0009880 IEA
    peptide transport GO:0015833 ISS
    patched ligand maturation GO:0007225 IEA
    smoothened signaling pathway GO:0007224 NAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified DISP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DISP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DISP1 is involved
No pathways found





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