Gene description for DISP1
Gene name dispatched homolog 1 (Drosophila)
Gene symbol DISP1
Other names/aliases DISPA
Species Homo sapiens
 Database cross references - DISP1
ExoCarta ExoCarta_84976
Vesiclepedia VP_84976
Entrez Gene 84976
HGNC 19711
MIM 607502
UniProt Q96F81  
 DISP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DISP1
Molecular Function
    protein binding GO:0005515 IPI
    peptide transmembrane transporter activity GO:1904680 ISS
Biological Process
    smoothened signaling pathway GO:0007224 IBA
    patched ligand maturation GO:0007225 IEA
    determination of left/right symmetry GO:0007368 IEA
    embryonic pattern specification GO:0009880 IEA
    dorsal/ventral pattern formation GO:0009953 IEA
    peptide transport GO:0015833 ISS
    transmembrane transport GO:0055085 IEA
    diaphragm development GO:0060539 IMP
Subcellular Localization
    membrane GO:0016020 IBA
 Experiment description of studies that identified DISP1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DISP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C15orf32  
Affinity Capture-MS Homo sapiens
2 JCHAIN 3512
Affinity Capture-MS Homo sapiens
3 EID1  
Affinity Capture-MS Homo sapiens
4 CST2  
Affinity Capture-MS Homo sapiens
5 LAPTM5 7805
Two-hybrid Homo sapiens
6 IL17RC 84818
Affinity Capture-MS Homo sapiens
7 FBXW8 26259
Affinity Capture-MS Homo sapiens
8 CUL3 8452
Affinity Capture-MS Homo sapiens
9 CST4 1472
Affinity Capture-MS Homo sapiens
10 RNF133  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DISP1 is involved
No pathways found





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