Gene description for GM2A
Gene name GM2 ganglioside activator
Gene symbol GM2A
Other names/aliases GM2-AP
SAP-3
Species Homo sapiens
 Database cross references - GM2A
ExoCarta ExoCarta_2760
Entrez Gene 2760
HGNC 4367
MIM 613109
UniProt P17900  
 GM2A identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
Urine 19056867    
 Gene ontology annotations for GM2A
Molecular Function
    beta-N-acetylgalactosaminidase activity GO:0032428 IEA
    lipid transporter activity GO:0005319 IEA
    phospholipase activator activity GO:0016004 IEA
Biological Process
    oligosaccharide catabolic process GO:0009313 IEA
    sphingolipid metabolic process GO:0006665 TAS
    lipid storage GO:0019915 IEA
    positive regulation of hydrolase activity GO:0051345 IEA
    ganglioside catabolic process GO:0006689 IEA
    lipid transport GO:0006869 IEA
    glycosphingolipid metabolic process GO:0006687 TAS
    small molecule metabolic process GO:0044281 TAS
    learning or memory GO:0007611 IEA
    neuromuscular process controlling balance GO:0050885 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    mitochondrion GO:0005739 IEA
    apical cortex GO:0045179 IEA
    cytoplasmic side of plasma membrane GO:0009898 IEA
    hydrogen:potassium-exchanging ATPase complex GO:0005889 IEA
    lysosomal lumen GO:0043202 TAS
 Experiment description of studies that identified GM2A in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GM2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HEXA 3073
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
2 PLD2 5338
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which GM2A is involved
PathwayEvidenceSource
Glycosphingolipid metabolism TAS Reactome





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