Gene description for ETHE1
Gene name ethylmalonic encephalopathy 1
Gene symbol ETHE1
Other names/aliases HSCO
YF13H12
Species Homo sapiens
 Database cross references - ETHE1
ExoCarta ExoCarta_23474
Entrez Gene 23474
HGNC 23287
MIM 608451
UniProt O95571  
 ETHE1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for ETHE1
Molecular Function
    sulfur dioxygenase activity GO:0050313 TAS
    iron ion binding GO:0005506 IDA
Biological Process
    sulfur amino acid catabolic process GO:0000098 TAS
    small molecule metabolic process GO:0044281 TAS
    glutathione metabolic process GO:0006749 IDA
    sulfur amino acid metabolic process GO:0000096 TAS
    sulfide oxidation, using sulfide:quinone oxidoreductase GO:0070221 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    hydrogen sulfide metabolic process GO:0070813 IDA
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified ETHE1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ETHE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGC15730  
Two-hybrid Homo sapiens
2 RELA  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ETHE1 is involved
PathwayEvidenceSource
Sulfide oxidation to sulfate TAS Reactome





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