Gene description for DRG2
Gene name developmentally regulated GTP binding protein 2
Gene symbol DRG2
Other names/aliases -
Species Homo sapiens
 Database cross references - DRG2
ExoCarta ExoCarta_1819
Entrez Gene 1819
HGNC 3030
MIM 602986
UniProt P55039  
 DRG2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Thymus 23844026    
 Gene ontology annotations for DRG2
Molecular Function
    GTP binding GO:0005525 IEA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    mitochondrion GO:0005739 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified DRG2 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DRG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RWDD1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DRG2 is involved
No pathways found





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