ExoCarta: Gene summary

Credits | Contact

Gene description for MAPK13
Gene name	mitogen-activated protein kinase 13
Gene symbol	MAPK13
Other names/aliases	MAPK 13 MAPK-13 PRKM13 SAPK4 p38delta
Species	Homo sapiens
Database cross references - MAPK13
ExoCarta	ExoCarta_5603
Vesiclepedia	VP_5603
Entrez Gene	5603
HGNC	6875
MIM	602899
UniProt	O15264
MAPK13 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for MAPK13

Molecular Function
	protein serine/threonine kinase activity	GO:0004674	IDA
	MAP kinase activity	GO:0004707	IDA
	ATP binding	GO:0005524	IEA
	protein binding	GO:0005515	IPI
Biological Process
	Ras protein signal transduction	GO:0007265	TAS
	peptidyl-serine phosphorylation	GO:0018105	IDA
	regulation of transcription, DNA-templated	GO:0006355	IEA
	intracellular signal transduction	GO:0035556	IDA
	transcription, DNA-templated	GO:0006351	IEA
	MAPK cascade	GO:0000165	IEA
	response to stress	GO:0006950	IDA
	positive regulation of inflammatory response	GO:0050729	IC
	positive regulation of interleukin-6 production	GO:0032755	IMP
	neurotrophin TRK receptor signaling pathway	GO:0048011	TAS
	cell cycle	GO:0007049	IEA
	vascular endothelial growth factor receptor signaling pathway	GO:0048010	TAS
	response to osmotic stress	GO:0006970	IDA
Subcellular Localization
	cytosol	GO:0005829	TAS

Experiment description of studies that identified MAPK13 in exosomes

Experiment ID

1203

MISEV standards
✔ EM	EV Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	EV Enriched markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for MAPK13

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

FGF12

Biochemical Activity

Homo sapiens

ATF2

Biochemical Activity

Homo sapiens

MAPKAPK3

7867

Affinity Capture-MS

Homo sapiens

SMAD4

Affinity Capture-MS

Homo sapiens

MAPK8IP2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

MAP3K4

4216

Invitro		Homo sapiens
Invivo		Homo sapiens

View the network

Pathways in which MAPK13 is involved

Pathway	Evidence	Source
DSCAM interactions	TAS	Reactome
NOD1/2 Signaling Pathway	TAS	Reactome
p38MAPK events	TAS	Reactome
VEGFA-VEGFR2 Pathway	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here