ExoCarta: Gene summary

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Gene description for MAPK13
Gene name	mitogen-activated protein kinase 13
Gene symbol	MAPK13
Other names/aliases	MAPK 13 MAPK-13 PRKM13 SAPK4 p38delta
Species	Homo sapiens
Database cross references - MAPK13
ExoCarta	ExoCarta_5603
Vesiclepedia	VP_5603
Entrez Gene	5603
HGNC	6875
MIM	602899
UniProt	O15264
MAPK13 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for MAPK13

Molecular Function
	protein serine/threonine kinase activity	GO:0004674	IBA
	protein serine/threonine kinase activity	GO:0004674	IDA
	JUN kinase activity	GO:0004705	IEA
	MAP kinase activity	GO:0004707	IDA
	protein binding	GO:0005515	IPI
	ATP binding	GO:0005524	IEA
	protein serine kinase activity	GO:0106310	IEA
Biological Process
	response to osmotic stress	GO:0006970	IDA
	JNK cascade	GO:0007254	IEA
	peptidyl-serine phosphorylation	GO:0018105	IDA
	positive regulation of interleukin-6 production	GO:0032755	IMP
	cellular response to UV	GO:0034644	IDA
	intracellular signal transduction	GO:0035556	IBA
	positive regulation of inflammatory response	GO:0050729	IC
	stress-activated MAPK cascade	GO:0051403	IDA
	cellular response to hydrogen peroxide	GO:0070301	IDA
	cellular response to interleukin-1	GO:0071347	IDA
	cellular response to sorbitol	GO:0072709	IDA
	cellular response to anisomycin	GO:0072740	IDA
	cellular response to sodium arsenite	GO:1903936	IDA
Subcellular Localization
	nucleus	GO:0005634	IBA
	cytoplasm	GO:0005737	IBA
	cytosol	GO:0005829	TAS

Experiment description of studies that identified MAPK13 in sEVs

Experiment ID

1203

MISEV standards
✔ EM	Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for MAPK13

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

APP

351

Reconstituted Complex

Homo sapiens

SQSTM1

8878

Biochemical Activity

Homo sapiens

FGF12

Biochemical Activity

Homo sapiens

ATF2

Biochemical Activity

Homo sapiens

MAPKAPK3

7867

Co-localization

Homo sapiens

GPX4

2879

Two-hybrid

Homo sapiens

ANKLE2

23141

Two-hybrid

Homo sapiens

MAPT

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

POTEF

728378

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SMAD4

Two-hybrid

Homo sapiens

AKIP1

Two-hybrid

Homo sapiens

MAPK12

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VCP

7415

Affinity Capture-MS

Homo sapiens

STX17

55014

Affinity Capture-MS

Homo sapiens

DRG2

1819

Affinity Capture-MS

Homo sapiens

MBP

4155

Biochemical Activity

Homo sapiens

MAPK8IP2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

MAP3K4

4216

Co-localization

Homo sapiens

HTRA2

27429

Biochemical Activity

Homo sapiens

View the network

Pathways in which MAPK13 is involved

Pathway	Evidence	Source
Immune System	TAS	Reactome
Innate Immune System	TAS	Reactome
NOD1/2 Signaling Pathway	TAS	Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS	Reactome
p38MAPK events	IEA	Reactome
Signal Transduction	TAS	Reactome
Signal Transduction	IEA	Reactome
Signaling by NTRK1 (TRKA)	IEA	Reactome
Signaling by NTRKs	IEA	Reactome
Signaling by Receptor Tyrosine Kinases	TAS	Reactome
Signaling by Receptor Tyrosine Kinases	IEA	Reactome
Signaling by VEGF	TAS	Reactome
Signalling to ERKs	IEA	Reactome
Signalling to RAS	IEA	Reactome
VEGFA-VEGFR2 Pathway	TAS	Reactome

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