Gene description for BDNF
Gene name brain-derived neurotrophic factor
Gene symbol BDNF
Other names/aliases ANON2
BULN2
Species Homo sapiens
 Database cross references - BDNF
ExoCarta ExoCarta_627
Vesiclepedia VP_627
Entrez Gene 627
HGNC 1033
MIM 113505
UniProt P23560  
 BDNF identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for BDNF
Molecular Function
    neurotrophin TRKB receptor binding GO:0005169 IBA
    growth factor activity GO:0008083 IEA
Biological Process
    cellular response to norepinephrine stimulus GO:0071874 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    gamma-aminobutyric acid signaling pathway GO:0007214 IEA
    positive regulation of long-term neuronal synaptic plasticity GO:0048170 IEA
    negative regulation of neuroblast proliferation GO:0007406 IEA
    response to fluoxetine GO:0014076 IEA
    regulation of neuron differentiation GO:0045664 IBA
    regulation of retinal cell programmed cell death GO:0046668 IEA
    axon extension GO:0048675 IEA
    response to vitamin A GO:0033189 IEA
    learning GO:0007612 IEA
    circadian rhythm GO:0007623 IEA
    response to hyperoxia GO:0055093 IEA
    axon target recognition GO:0007412 IEA
    response to hypoxia GO:0001666 IEA
    response to potassium ion GO:0035864 IEA
    response to hormone GO:0009725 IEA
    taste bud development GO:0061193 IEA
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 IEA
    neuron recognition GO:0008038 IEA
    inner ear development GO:0048839 IEA
    response to activity GO:0014823 IEA
    regulation of axon extension GO:0030516 IEA
    nerve development GO:0021675 IEA
    response to food GO:0032094 IEA
    dendrite extension GO:0097484 IEA
    negative regulation of synaptic transmission, GABAergic GO:0032229 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    response to light intensity GO:0009642 IEA
    nervous system development GO:0007399 TAS
    behavioral fear response GO:0001662 IEA
    cellular response to nerve growth factor stimulus GO:1990090 IEA
    regulation of excitatory postsynaptic membrane potential GO:0060079 IEA
    response to L-glutamate GO:1902065 IEA
    response to electrical stimulus GO:0051602 IEA
    regulation of short-term neuronal synaptic plasticity GO:0048172 IEA
    response to auditory stimulus GO:0010996 IEA
    neuron projection morphogenesis GO:0048812 IBA
    dendrite development GO:0016358 IEA
    negative regulation of striated muscle tissue development GO:0045843 IEA
    axon guidance GO:0007411 IEA
    positive regulation of synapse assembly GO:0051965 IDA
    mechanoreceptor differentiation GO:0042490 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    response to anesthetic GO:0072347 IEA
    negative regulation of neuron apoptotic process GO:0043524 IBA
    chronic inflammatory response GO:0002544 IEA
    cell-cell signaling GO:0007267 IBA
    glutamate secretion GO:0014047 IEA
    ureteric bud development GO:0001657 IEA
    positive regulation of neuron differentiation GO:0045666 IEA
    feeding behavior GO:0007631 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    synaptic vesicle GO:0008021 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IBA
    mitochondrial crista GO:0030061 IEA
    terminal bouton GO:0043195 IEA
    perikaryon GO:0043204 IEA
    perinuclear region of cytoplasm GO:0048471 ISS
    dendrite GO:0030425 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified BDNF in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for BDNF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NTF5  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 NTRK2 4915
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which BDNF is involved
No pathways found





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