Gene description for C4BPB
Gene name complement component 4 binding protein, beta
Gene symbol C4BPB
Other names/aliases C4BP
Species Homo sapiens
 Database cross references - C4BPB
ExoCarta ExoCarta_725
Vesiclepedia VP_725
Entrez Gene 725
HGNC 1328
MIM 120831
UniProt P20851  
 C4BPB identified in sEVs derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for C4BPB
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    complement activation, classical pathway GO:0006958 IEA
    blood coagulation GO:0007596 TAS
    response to symbiotic bacterium GO:0009609 IDA
    innate immune response GO:0045087 IEA
    positive regulation of protein catabolic process GO:0045732 IDA
    negative regulation of complement activation, classical pathway GO:0045959 IDA
    regulation of opsonization GO:1903027 IDA
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified C4BPB in sEVs
1
Experiment ID 44
MISEV standards
✔
IEM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for C4BPB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 DCTN3 11258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 KIF14 9928
Affinity Capture-MS Homo sapiens
4 TP53 7157
Affinity Capture-MS Homo sapiens
5 DCTN6 10671
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VPS52 6293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LAMB2 3913
Affinity Capture-MS Homo sapiens
8 PROS1 5627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC25A15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ERLEC1 27248
Affinity Capture-MS Homo sapiens
11 MRPL10 124995
Affinity Capture-MS Homo sapiens
12 ACTR1B 10120
Affinity Capture-MS Homo sapiens
13 MTO1  
Affinity Capture-MS Homo sapiens
14 BDNF 627
Affinity Capture-MS Homo sapiens
15 GGCX 2677
Affinity Capture-MS Homo sapiens
16 SLC25A16  
Affinity Capture-MS Homo sapiens
17 SEMA3B 7869
Affinity Capture-MS Homo sapiens
18 KLHL22 84861
Affinity Capture-MS Homo sapiens
19 FBXO2 26232
Affinity Capture-MS Homo sapiens
20 DCTN4 51164
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NEK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 OLFM2  
Affinity Capture-MS Homo sapiens
23 ZNF655  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SEL1L 6400
Affinity Capture-MS Homo sapiens
25 FAM127A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC25A30 253512
Affinity Capture-MS Homo sapiens
27 PCSK6 5046
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which C4BPB is involved
PathwayEvidenceSource
Complement cascade TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Regulation of Complement cascade TAS Reactome





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