Gene description for C4BPB
Gene name complement component 4 binding protein, beta
Gene symbol C4BPB
Other names/aliases C4BP
Species Homo sapiens
 Database cross references - C4BPB
ExoCarta ExoCarta_725
Entrez Gene 725
HGNC 1328
MIM 120831
UniProt P20851  
 C4BPB identified in exosomes derived from the following tissue/cell type
Plasma 19028452    
 Gene ontology annotations for C4BPB
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of complement activation, classical pathway GO:0045959 IDA
    innate immune response GO:0045087 TAS
    positive regulation of protein catabolic process GO:0045732 IDA
    complement activation, classical pathway GO:0006958 IEA
    blood coagulation GO:0007596 TAS
    regulation of opsonization GO:1903027 IC
    regulation of complement activation GO:0030449 TAS
Subcellular Localization
    extracellular region GO:0005576 NAS
    other organism cell GO:0044216 IDA
    plasma membrane GO:0005886 TAS
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified C4BPB in exosomes
1
Experiment ID 44
ISEV standards
✔
IEM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for C4BPB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C4BPB is involved
PathwayEvidenceSource
Regulation of Complement cascade TAS Reactome





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