Gene description for NTRK2
Gene name	neurotrophic tyrosine kinase, receptor, type 2
Gene symbol	NTRK2
Other names/aliases	GP145-TrkB TRKB trk-B
Species	Homo sapiens
Database cross references - NTRK2
ExoCarta	ExoCarta_4915
Entrez Gene	4915
HGNC	8032
MIM	600456
UniProt	Q16620
NTRK2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for NTRK2

Molecular Function     neurotrophin binding GO:0043121 ISS     protein homodimerization activity GO:0042803 ISS     ephrin receptor binding GO:0046875 IEA     ATP binding GO:0005524 IEA     brain-derived neurotrophic factor-activated receptor activity GO:0060175 IMP     brain-derived neurotrophic factor binding GO:0048403 ISS Biological Process     positive regulation of gene expression GO:0010628 ISS     vasculogenesis GO:0001570 IEA     learning GO:0007612 ISS     negative regulation of anoikis GO:2000811 IEA     central nervous system neuron development GO:0021954 ISS     oligodendrocyte differentiation GO:0048709 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     aging GO:0007568 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IEA     glutamate secretion GO:0014047 IEA     long-term memory GO:0007616 IEA     mechanoreceptor differentiation GO:0042490 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS     negative regulation of neuron apoptotic process GO:0043524 ISS     positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA     protein autophosphorylation GO:0046777 ISS     positive regulation of MAPK cascade GO:0043410 ISS     cellular response to nerve growth factor stimulus GO:1990090 IEA     regulation of neurotransmitter secretion GO:0046928 IEA     cellular response to tumor necrosis factor GO:0071356 IEA     regulation of dendrite development GO:0050773 IEA     activation of adenylate cyclase activity GO:0007190 TAS     neuron migration GO:0001764 ISS     response to light stimulus GO:0009416 IEA     long-term synaptic potentiation GO:0060291 IEA     feeding behavior GO:0007631 IEA     regulation of GTPase activity GO:0043087 ISS     neuromuscular junction development GO:0007528 IEA     response to auditory stimulus GO:0010996 IEA     positive regulation of neuron projection development GO:0010976 ISS     positive regulation of cell proliferation GO:0008284 ISS     neuron differentiation GO:0030182 ISS     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IMP     calcium-mediated signaling using intracellular calcium source GO:0035584 IEA     peripheral nervous system neuron development GO:0048935 IEA     positive regulation of axonogenesis GO:0050772 ISS     circadian rhythm GO:0007623 IEA     regulation of protein kinase B signaling GO:0051896 IEA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     cerebral cortex development GO:0021987 ISS     inflammatory response GO:0006954 IEA     retinal rod cell development GO:0046548 IEA Subcellular Localization     cell surface GO:0009986 IEA     excitatory synapse GO:0060076 IEA     presynaptic active zone GO:0048786 IEA     cytosol GO:0005829 IEA     growth cone GO:0030426 IEA     postsynaptic membrane GO:0045211 IEA     integral component of plasma membrane GO:0005887 IDA     neuronal postsynaptic density GO:0097481 IEA     rough endoplasmic reticulum GO:0005791 IEA     dendritic spine GO:0043197 IEA     perikaryon GO:0043204 IEA     receptor complex GO:0043235 IDA     terminal bouton GO:0043195 IEA     endosome membrane GO:0010008 IEA