Gene description for NTRK2
Gene name neurotrophic tyrosine kinase, receptor, type 2
Gene symbol NTRK2
Other names/aliases GP145-TrkB
Species Homo sapiens
 Database cross references - NTRK2
ExoCarta ExoCarta_4915
Entrez Gene 4915
HGNC 8032
MIM 600456
UniProt Q16620  
 NTRK2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for NTRK2
Molecular Function
    neurotrophin binding GO:0043121 ISS
    protein homodimerization activity GO:0042803 ISS
    ephrin receptor binding GO:0046875 IEA
    ATP binding GO:0005524 IEA
    brain-derived neurotrophic factor-activated receptor activity GO:0060175 IMP
    brain-derived neurotrophic factor binding GO:0048403 ISS
Biological Process
    positive regulation of gene expression GO:0010628 ISS
    vasculogenesis GO:0001570 IEA
    learning GO:0007612 ISS
    negative regulation of anoikis GO:2000811 IEA
    central nervous system neuron development GO:0021954 ISS
    oligodendrocyte differentiation GO:0048709 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    aging GO:0007568 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    glutamate secretion GO:0014047 IEA
    long-term memory GO:0007616 IEA
    mechanoreceptor differentiation GO:0042490 IEA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    protein autophosphorylation GO:0046777 ISS
    positive regulation of MAPK cascade GO:0043410 ISS
    cellular response to nerve growth factor stimulus GO:1990090 IEA
    regulation of neurotransmitter secretion GO:0046928 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    regulation of dendrite development GO:0050773 IEA
    activation of adenylate cyclase activity GO:0007190 TAS
    neuron migration GO:0001764 ISS
    response to light stimulus GO:0009416 IEA
    long-term synaptic potentiation GO:0060291 IEA
    feeding behavior GO:0007631 IEA
    regulation of GTPase activity GO:0043087 ISS
    neuromuscular junction development GO:0007528 IEA
    response to auditory stimulus GO:0010996 IEA
    positive regulation of neuron projection development GO:0010976 ISS
    positive regulation of cell proliferation GO:0008284 ISS
    neuron differentiation GO:0030182 ISS
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IMP
    calcium-mediated signaling using intracellular calcium source GO:0035584 IEA
    peripheral nervous system neuron development GO:0048935 IEA
    positive regulation of axonogenesis GO:0050772 ISS
    circadian rhythm GO:0007623 IEA
    regulation of protein kinase B signaling GO:0051896 IEA
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    cerebral cortex development GO:0021987 ISS
    inflammatory response GO:0006954 IEA
    retinal rod cell development GO:0046548 IEA
Subcellular Localization
    cell surface GO:0009986 IEA
    excitatory synapse GO:0060076 IEA
    presynaptic active zone GO:0048786 IEA
    cytosol GO:0005829 IEA
    growth cone GO:0030426 IEA
    postsynaptic membrane GO:0045211 IEA
    integral component of plasma membrane GO:0005887 IDA
    neuronal postsynaptic density GO:0097481 IEA
    rough endoplasmic reticulum GO:0005791 IEA
    dendritic spine GO:0043197 IEA
    perikaryon GO:0043204 IEA
    receptor complex GO:0043235 IDA
    terminal bouton GO:0043195 IEA
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified NTRK2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for NTRK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCK1 4690
Two-hybrid Homo sapiens
2 NCK2 8440
Invitro Homo sapiens
Two-hybrid Homo sapiens
3 NTF3  
Reconstituted Complex Homo sapiens
4 PLCG1 5335
Reconstituted Complex Homo sapiens
5 SHC3  
Invivo Homo sapiens
6 FRS2  
Reconstituted Complex Homo sapiens
7 GIPC1 10755
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
8 SQSTM1 8878
Invivo Homo sapiens
9 FYN 2534
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 SHC1 6464
Reconstituted Complex Homo sapiens
11 NTF5  
Invivo Homo sapiens
12 DYNLL1 8655
Affinity Capture-Western Homo sapiens
13 PTPN1 5770
Invitro Homo sapiens
14 BDNF 627
Invivo Homo sapiens
Invitro Homo sapiens
15 FRS3  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which NTRK2 is involved
NGF-independant TRKA activation TAS Reactome

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