Gene description for SH2B1
Gene name SH2B adaptor protein 1
Gene symbol SH2B1
Other names/aliases PSM
Species Homo sapiens
 Database cross references - SH2B1
ExoCarta ExoCarta_25970
Entrez Gene 25970
HGNC 30417
MIM 608937
UniProt Q9NRF2  
 SH2B1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SH2B1
Molecular Function
    protein binding GO:0005515 IPI
    signal transducer activity GO:0004871 IEA
    signaling adaptor activity GO:0035591 IEA
Biological Process
    blood coagulation GO:0007596 TAS
    positive regulation of mitotic nuclear division GO:0045840 IEA
    intracellular signal transduction GO:0035556 IEA
    positive regulation of signal transduction GO:0009967 IEA
    lamellipodium assembly GO:0030032 IEA
    regulation of DNA biosynthetic process GO:2000278 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SH2B1 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SH2B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGFR3 2261
Affinity Capture-Western Homo sapiens
2 JAK2 3717
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 INSR 3643
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
4 NTRK1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 GRB2 2885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 BCR 613
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SH2B1 is involved
Factors involved in megakaryocyte development and platelet production TAS Reactome

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