Gene description for TMEM132A
Gene name transmembrane protein 132A
Gene symbol TMEM132A
Other names/aliases GBP
HSPA5BP1
Species Homo sapiens
 Database cross references - TMEM132A
ExoCarta ExoCarta_54972
Vesiclepedia VP_54972
Entrez Gene 54972
HGNC 31092
UniProt Q24JP5  
 TMEM132A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TMEM132A
Molecular Function
    protein homodimerization activity GO:0042803 IEA
Biological Process
    positive regulation of Wnt signaling pathway GO:0030177 IEA
    negative regulation of protein catabolic process GO:0042177 IEA
    positive regulation of Wnt protein secretion GO:0061357 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TMEM132A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TMEM132A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LILRA5  
Affinity Capture-MS Homo sapiens
2 KLK15  
Affinity Capture-MS Homo sapiens
3 CEACAM8 1088
Affinity Capture-MS Homo sapiens
4 MITD1 129531
Affinity Capture-MS Homo sapiens
5 PCDHGA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 PCDHGB4 8641
Affinity Capture-MS Homo sapiens
7 LIMS1 3987
Affinity Capture-MS Homo sapiens
8 MFAP4 4239
Affinity Capture-MS Homo sapiens
9 UBC 7316
Reconstituted Complex Homo sapiens
10 KIR3DL2  
Affinity Capture-MS Homo sapiens
11 CELA3A  
Affinity Capture-MS Homo sapiens
12 SCLT1 132320
Affinity Capture-MS Homo sapiens
13 MYH6 4624
Affinity Capture-MS Homo sapiens
14 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TRIOBP 11078
Affinity Capture-MS Homo sapiens
16 TSHR 7253
Affinity Capture-MS Homo sapiens
17 ST8SIA5  
Affinity Capture-MS Homo sapiens
18 NCOA3  
Affinity Capture-MS Homo sapiens
19 MPPE1 65258
Affinity Capture-MS Homo sapiens
20 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SLC1A5 6510
Affinity Capture-MS Homo sapiens
22 WDFY3 23001
Affinity Capture-MS Homo sapiens
23 BTNL2  
Affinity Capture-MS Homo sapiens
24 TMEM106A  
Affinity Capture-MS Homo sapiens
25 C1QTNF9B  
Affinity Capture-MS Homo sapiens
26 TMEM87A 25963
Affinity Capture-MS Homo sapiens
27 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
28 ENOPH1 58478
Affinity Capture-MS Homo sapiens
29 KLF16  
Affinity Capture-MS Homo sapiens
30 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 EFNA2  
Affinity Capture-MS Homo sapiens
33 TRGV3  
Affinity Capture-MS Homo sapiens
34 ATG2A  
Affinity Capture-MS Homo sapiens
35 CANT1 124583
Affinity Capture-MS Homo sapiens
36 TMED6  
Affinity Capture-MS Homo sapiens
37 CEP55 55165
Affinity Capture-MS Homo sapiens
38 FUT8 2530
Affinity Capture-MS Homo sapiens
39 ANTXR1 84168
Affinity Capture-MS Homo sapiens
40 LYZL6  
Affinity Capture-MS Homo sapiens
41 GOLGA2 2801
Affinity Capture-MS Homo sapiens
42 FYN 2534
Affinity Capture-MS Homo sapiens
43 SDF2L1 23753
Affinity Capture-MS Homo sapiens
44 FIBIN  
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 CRISP2  
Affinity Capture-MS Homo sapiens
47 C1orf54  
Affinity Capture-MS Homo sapiens
48 BRICD5  
Affinity Capture-MS Homo sapiens
49 TDGF1  
Affinity Capture-MS Homo sapiens
50 GCC1 79571
Affinity Capture-MS Homo sapiens
51 ICAM5 7087
Affinity Capture-MS Homo sapiens
52 HS3ST2  
Affinity Capture-MS Homo sapiens
53 PCDHGC5  
Affinity Capture-MS Homo sapiens
54 GOLGA5 9950
Affinity Capture-MS Homo sapiens
55 LY86  
Affinity Capture-MS Homo sapiens
56 PCDHA8  
Affinity Capture-MS Homo sapiens
57 C7orf34  
Affinity Capture-MS Homo sapiens
58 SMYD5 10322
Affinity Capture-MS Homo sapiens
59 HSPA5 3309
Reconstituted Complex Homo sapiens
60 ARL6IP4  
Affinity Capture-MS Homo sapiens
61 PCDH20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CALR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 USP15 9958
Affinity Capture-MS Homo sapiens
65 C1QA 712
Affinity Capture-MS Homo sapiens
66 SIGLEC10  
Affinity Capture-MS Homo sapiens
67 B3GNT3 10331
Affinity Capture-MS Homo sapiens
68 PDGFRA 5156
Affinity Capture-MS Homo sapiens
69 PRG2  
Affinity Capture-MS Homo sapiens
70 CBLN4  
Affinity Capture-MS Homo sapiens
71 GAA 2548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 COX6B1 1340
Affinity Capture-MS Homo sapiens
73 IL5RA  
Affinity Capture-MS Homo sapiens
74 NPTX1  
Affinity Capture-MS Homo sapiens
75 EPHA7 2045
Affinity Capture-MS Homo sapiens
76 LYZL1  
Affinity Capture-MS Homo sapiens
77 C1QB 713
Affinity Capture-MS Homo sapiens
78 PTPRK 5796
Affinity Capture-MS Homo sapiens
79 SCGB2A2  
Affinity Capture-MS Homo sapiens
80 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
81 CST9L  
Affinity Capture-MS Homo sapiens
82 KIAA0368 23392
Affinity Capture-MS Homo sapiens
83 ARGLU1  
Affinity Capture-MS Homo sapiens
84 MAGT1 84061
Affinity Capture-MS Homo sapiens
85 IRF3 3661
Affinity Capture-MS Homo sapiens
86 NDST1 3340
Affinity Capture-MS Homo sapiens
87 NES 10763
Affinity Capture-MS Homo sapiens
88 FZD6 8323
Affinity Capture-MS Homo sapiens
89 SPCS3 60559
Affinity Capture-MS Homo sapiens
90 MFHAS1 9258
Affinity Capture-MS Homo sapiens
91 NAAA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 SIAE 54414
Affinity Capture-MS Homo sapiens
93 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
94 IGLL5 100423062
Affinity Capture-MS Homo sapiens
95 ALPPL2 251
Affinity Capture-MS Homo sapiens
96 ASIC4  
Affinity Capture-MS Homo sapiens
97 PNLIPRP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 MGAT4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 NCR3  
Affinity Capture-MS Homo sapiens
100 SLAMF1 6504
Affinity Capture-MS Homo sapiens
101 RAD50 10111
Affinity Capture-MS Homo sapiens
102 CLEC12B  
Affinity Capture-MS Homo sapiens
103 WWP2 11060
Affinity Capture-MS Homo sapiens
104 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GNB1L 54584
Affinity Capture-MS Homo sapiens
106 SIRPD  
Affinity Capture-MS Homo sapiens
107 MOV10 4343
Affinity Capture-RNA Homo sapiens
108 SEC62 7095
Affinity Capture-MS Homo sapiens
109 PCDHGA9  
Affinity Capture-MS Homo sapiens
110 STX3 6809
Affinity Capture-MS Homo sapiens
111 DBI 1622
Affinity Capture-MS Homo sapiens
112 PAPSS1 9061
Affinity Capture-MS Homo sapiens
113 CST11  
Affinity Capture-MS Homo sapiens
114 PCDHB3  
Affinity Capture-MS Homo sapiens
115 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
116 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 LYPD2  
Affinity Capture-MS Homo sapiens
118 HLA-C 3107
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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