Gene description for SCLT1
Gene name sodium channel and clathrin linker 1
Gene symbol SCLT1
Other names/aliases CAP-1A
CAP1A
Species Homo sapiens
 Database cross references - SCLT1
ExoCarta ExoCarta_132320
Vesiclepedia VP_132320
Entrez Gene 132320
HGNC 26406
MIM 611399
UniProt Q96NL6  
 SCLT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SCLT1
Molecular Function
    protein binding GO:0005515 IPI
    sodium channel regulator activity GO:0017080 IEA
    clathrin binding GO:0030276 IEA
Biological Process
    clustering of voltage-gated sodium channels GO:0045162 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 IMP
    cilium assembly GO:0060271 IMP
Subcellular Localization
    centrosome GO:0005813 IDA
    centriole GO:0005814 IBA
    centriole GO:0005814 IDA
    cytosol GO:0005829 TAS
    clathrin complex GO:0071439 IEA
    ciliary transition fiber GO:0097539 IDA
 Experiment description of studies that identified SCLT1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SCLT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TBCA 6902
Cross-Linking-MS (XL-MS) Homo sapiens
2 KIZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 AMOT  
Affinity Capture-MS Homo sapiens
4 Osgep  
Affinity Capture-MS Mus musculus
5 EXOC3 11336
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 Gpkow  
Affinity Capture-MS Mus musculus
7 NINL  
Proximity Label-MS Homo sapiens
8 BFSP1  
Affinity Capture-MS Homo sapiens
9 IKBKG 8517
Reconstituted Complex Homo sapiens
10 NHLRC2 374354
Affinity Capture-MS Homo sapiens
11 CALM1 801
Reconstituted Complex Homo sapiens
12 ANKRD30A 91074
Affinity Capture-MS Homo sapiens
13 TPM1 7168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ING1  
Affinity Capture-MS Homo sapiens
15 TMEM132A 54972
Affinity Capture-MS Homo sapiens
16 NIN 51199
Proximity Label-MS Homo sapiens
17 Kif13b  
Affinity Capture-MS Mus musculus
18 FGFR1OP  
Affinity Capture-MS Homo sapiens
19 CCDC14  
Affinity Capture-MS Homo sapiens
20 NDC80 10403
Proximity Label-MS Homo sapiens
21 BICD1 636
Proximity Label-MS Homo sapiens
22 Brca1  
Affinity Capture-MS Mus musculus
23 PCM1 5108
Proximity Label-MS Homo sapiens
24 SYCE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 Fgfr1op  
Affinity Capture-MS Mus musculus
26 LNX1  
Reconstituted Complex Homo sapiens
27 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CENPQ  
Affinity Capture-MS Homo sapiens
29 Cep135  
Affinity Capture-MS Mus musculus
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