Gene description for ISOC1
Gene name isochorismatase domain containing 1
Gene symbol ISOC1
Other names/aliases CGI-111
Species Homo sapiens
 Database cross references - ISOC1
ExoCarta ExoCarta_51015
Vesiclepedia VP_51015
Entrez Gene 51015
HGNC 24254
UniProt Q96CN7  
 ISOC1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ISOC1
Molecular Function
    protein binding GO:0005515 IPI
Subcellular Localization
    cytoplasm GO:0005737 IBA
    peroxisome GO:0005777 ISS
 Experiment description of studies that identified ISOC1 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ISOC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Co-fractionation Homo sapiens
2 YWHAE 7531
Co-fractionation Homo sapiens
3 PAFAH1B1 5048
Co-fractionation Homo sapiens
4 CALCOCO1 57658
Two-hybrid Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 STK24 8428
Co-fractionation Homo sapiens
7 OGFOD1  
Co-fractionation Homo sapiens
8 G6PD 2539
Co-fractionation Homo sapiens
9 PTMA 5757
Co-fractionation Homo sapiens
10 ASNS 440
Co-fractionation Homo sapiens
11 PDIA4 9601
Co-fractionation Homo sapiens
12 VTN 7448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 DDHD1 80821
Affinity Capture-MS Homo sapiens
14 RPA2 6118
Proximity Label-MS Homo sapiens
15 CRABP2 1382
Co-fractionation Homo sapiens
16 FERMT2 10979
Co-fractionation Homo sapiens
17 DFFA 1676
Co-fractionation Homo sapiens
18 PAK2 5062
Co-fractionation Homo sapiens
19 PRCP 5547
Co-fractionation Homo sapiens
20 YWHAZ 7534
Co-fractionation Homo sapiens
21 TUBB4B 10383
Co-fractionation Homo sapiens
22 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
23 CAPNS1 826
Co-fractionation Homo sapiens
24 STK26 51765
Co-fractionation Homo sapiens
25 ERP44 23071
Co-fractionation Homo sapiens
26 CKB 1152
Co-fractionation Homo sapiens
27 BIRC6 57448
Affinity Capture-MS Homo sapiens
28 CUL9  
Affinity Capture-MS Homo sapiens
29 UBFD1 56061
Co-fractionation Homo sapiens
30 UMPS 7372
Co-fractionation Homo sapiens
31 PPP1R2 5504
Co-fractionation Homo sapiens
32 VCL 7414
Co-fractionation Homo sapiens
33 RPA3 6119
Proximity Label-MS Homo sapiens
34 IST1 9798
Affinity Capture-MS Homo sapiens
35 NTRK1 4914
Affinity Capture-MS Homo sapiens
36 PRKCA 5578
Affinity Capture-MS Homo sapiens
37 LACTB2 51110
Co-fractionation Homo sapiens
38 MYO1E 4643
Co-fractionation Homo sapiens
39 GNA13 10672
Affinity Capture-MS Homo sapiens
40 TBCB 1155
Co-fractionation Homo sapiens
41 MCTS1 28985
Co-fractionation Homo sapiens
42 ATIC 471
Co-fractionation Homo sapiens
43 ARHGAP8 23779
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MTHFD1L 25902
Co-fractionation Homo sapiens
45 EIF5 1983
Co-fractionation Homo sapiens
46 PROSC 11212
Co-fractionation Homo sapiens
47 PFAS 5198
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which ISOC1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here