Gene description for CRABP2
Gene name cellular retinoic acid binding protein 2
Gene symbol CRABP2
Other names/aliases CRABP-II
RBP6
Species Homo sapiens
 Database cross references - CRABP2
ExoCarta ExoCarta_1382
Entrez Gene 1382
HGNC 2339
MIM 180231
UniProt P29373  
 CRABP2 identified in exosomes derived from the following tissue/cell type
Breast cancer cells 19415654    
Urine 19056867    
 Gene ontology annotations for CRABP2
Molecular Function
    retinal binding GO:0016918 IEA
    retinol binding GO:0019841 IEA
    transporter activity GO:0005215 IEA
    protein binding GO:0005515 IPI
    retinoid binding GO:0005501 TAS
    retinoic acid binding GO:0001972 IEA
Biological Process
    embryonic forelimb morphogenesis GO:0035115 IEA
    transport GO:0006810 IEA
    retinoic acid biosynthetic process GO:0002138 IEA
    epidermis development GO:0008544 TAS
    signal transduction GO:0007165 TAS
    regulation of transcription, DNA-templated GO:0006355 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    endoplasmic reticulum GO:0005783 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CRABP2 in exosomes
1
Experiment ID 65
ISEV standards
✘ EV Biophysical techniques
✔
HSP60|HSP27|GAPDH
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19415654    
Organism Homo sapiens
Experiment description Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
Authors Staubach S, Razawi H, Hanisch FG.
Journal name PROTEOMICS
Publication year 2009
Sample Breast cancer cells
Sample name MCF-7
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRABP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRABP2 1382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CCND3  
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CRABP2 is involved
PathwayEvidenceSource
Signaling by Retinoic Acid TAS Reactome





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