Gene description for PRCP
Gene name prolylcarboxypeptidase (angiotensinase C)
Gene symbol PRCP
Other names/aliases HUMPCP
PCP
Species Homo sapiens
 Database cross references - PRCP
ExoCarta ExoCarta_5547
Entrez Gene 5547
HGNC 9344
MIM 176785
UniProt P42785  
 PRCP identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Urine 19056867    
 Gene ontology annotations for PRCP
Molecular Function
    serine-type carboxypeptidase activity GO:0004185 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of thyroid hormone mediated signaling pathway GO:0002155 IEA
    blood coagulation GO:0007596 TAS
    plasma kallikrein-kinin cascade GO:0002353 IEA
    blood coagulation, intrinsic pathway GO:0007597 TAS
    regulation of reactive oxygen species metabolic process GO:2000377 IEA
    angiogenesis involved in wound healing GO:0060055 IEA
    energy homeostasis GO:0097009 IEA
    glucose homeostasis GO:0042593 IEA
    regulation of blood vessel endothelial cell migration GO:0043535 IEA
    proteolysis GO:0006508 IEA
    negative regulation of systemic arterial blood pressure GO:0003085 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    lysosome GO:0005764 IEA
    basal part of cell GO:0045178 IEA
 Experiment description of studies that identified PRCP in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PRCP
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRCP is involved
PathwayEvidenceSource
Intrinsic Pathway of Fibrin Clot Formation TAS Reactome





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