Gene description for KIDINS220
Gene name kinase D-interacting substrate, 220kDa
Gene symbol KIDINS220
Other names/aliases ARMS
Species Homo sapiens
 Database cross references - KIDINS220
ExoCarta ExoCarta_57498
Entrez Gene 57498
HGNC 29508
MIM 615759
UniProt Q9ULH0  
 KIDINS220 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KIDINS220
Molecular Function
    PDZ domain binding GO:0030165 ISS
    protein kinase regulator activity GO:0019887 IBA
Biological Process
    regulation of protein kinase activity GO:0045859 IBA
    cytoplasmic transport GO:0016482 ISS
    in utero embryonic development GO:0001701 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    nerve growth factor signaling pathway GO:0038180 ISS
    dendrite morphogenesis GO:0048813 IEA
    cellular response to nerve growth factor stimulus GO:1990090 ISS
    activation of MAPKK activity GO:0000186 TAS
    positive regulation of neuron projection development GO:0010976 ISS
Subcellular Localization
    late endosome GO:0005770 ISS
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IDA
    nucleoplasm GO:0005654 IDA
    protein complex GO:0043234 ISS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified KIDINS220 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KIDINS220
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PREI3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which KIDINS220 is involved
PathwayEvidenceSource
ARMS-mediated activation TAS Reactome





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