Gene description for Ptpn23
Gene name protein tyrosine phosphatase, non-receptor type 23
Gene symbol Ptpn23
Other names/aliases AI462446
PTP-TD14
Species Mus musculus
 Database cross references - Ptpn23
ExoCarta ExoCarta_104831
Vesiclepedia VP_104831
Entrez Gene 104831
UniProt Q6PB44  
 Ptpn23 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ptpn23
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 ISO
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    negative regulation of epithelial cell migration GO:0010633 IEA
    negative regulation of epithelial cell migration GO:0010633 ISO
    protein transport GO:0015031 IEA
    endocytic recycling GO:0032456 IBA
    endocytic recycling GO:0032456 IEA
    endocytic recycling GO:0032456 ISO
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISO
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISS
    protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328 IBA
    early endosome to late endosome transport GO:0045022 IBA
    early endosome to late endosome transport GO:0045022 IEA
    early endosome to late endosome transport GO:0045022 ISO
    cilium assembly GO:0060271 ISO
    cilium assembly GO:0060271 ISS
    positive regulation of Wnt protein secretion GO:0061357 IEA
    positive regulation of Wnt protein secretion GO:0061357 ISO
    positive regulation of homophilic cell adhesion GO:1903387 IEA
    positive regulation of homophilic cell adhesion GO:1903387 ISO
    positive regulation of adherens junction organization GO:1903393 IEA
    positive regulation of adherens junction organization GO:1903393 ISO
    positive regulation of early endosome to late endosome transport GO:2000643 IEA
    positive regulation of early endosome to late endosome transport GO:2000643 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    endosome GO:0005768 ISS
    early endosome GO:0005769 ISO
    early endosome GO:0005769 ISS
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    ciliary basal body GO:0036064 ISO
    ciliary basal body GO:0036064 ISS
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ptpn23 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ptpn23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Affinity Capture-MS Homo sapiens
2 ABCG2 9429
Affinity Capture-MS Homo sapiens
3 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
4 ATP6V1B2 526
Affinity Capture-MS Homo sapiens
5 Usp8  
Co-fractionation Mus musculus
6 CHMP3 51652
Affinity Capture-MS Homo sapiens
7 Stam2  
Co-fractionation Mus musculus
8 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
9 MITD1 129531
Affinity Capture-MS Homo sapiens
10 CYBRD1 79901
Affinity Capture-MS Homo sapiens
11 PTRF 284119
Affinity Capture-MS Homo sapiens
12 C12orf4  
Affinity Capture-MS Homo sapiens
13 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
14 STOML2 30968
Affinity Capture-MS Homo sapiens
15 XPR1 9213
Affinity Capture-MS Homo sapiens
16 Atxn1  
Affinity Capture-MS Mus musculus
17 BST2 684
Affinity Capture-MS Homo sapiens
18 TSG101 7251
Affinity Capture-MS Homo sapiens
19 BAZ2B  
Affinity Capture-MS Homo sapiens
20 ZFYVE16  
Affinity Capture-MS Homo sapiens
21 PACSIN3 29763
Affinity Capture-MS Homo sapiens
22 CAPN7 23473
Affinity Capture-MS Homo sapiens
23 Ptk2  
Co-fractionation Mus musculus
24 Kif5b 16573
Co-fractionation Mus musculus
25 UMAD1  
Affinity Capture-MS Homo sapiens
26 IST1 9798
Affinity Capture-MS Homo sapiens
27 CHMP4B 128866
Affinity Capture-MS Homo sapiens
28 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
29 ATP6V1A 523
Affinity Capture-MS Homo sapiens
30 CLTA 1211
Affinity Capture-MS Homo sapiens
31 CHMP5 51510
Affinity Capture-MS Homo sapiens
32 Grb2 14784
Co-fractionation Mus musculus
33 SPAST 6683
Affinity Capture-MS Homo sapiens
34 CLTC 1213
Affinity Capture-MS Homo sapiens
35 Myo6  
Co-fractionation Mus musculus
36 KIDINS220 57498
Affinity Capture-MS Homo sapiens
37 CHMP2B 25978
Affinity Capture-MS Homo sapiens
38 STAMBP 10617
Affinity Capture-MS Homo sapiens
39 FLOT2 2319
Affinity Capture-MS Homo sapiens
40 CAV1 857
Affinity Capture-MS Homo sapiens
41 CHMP1B 57132
Affinity Capture-MS Homo sapiens
42 CTC1  
Affinity Capture-MS Homo sapiens
43 Pdcd6 18570
Co-fractionation Mus musculus
44 FLOT1 10211
Affinity Capture-MS Homo sapiens
45 TICRR 90381
Affinity Capture-MS Homo sapiens
46 CHMP1A 5119
Affinity Capture-MS Homo sapiens
47 GPRC5A 9052
Affinity Capture-MS Homo sapiens
48 CHMP4A 29082
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Ptpn23 is involved
No pathways found





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