Gene description for Pdcd6
Gene name programmed cell death 6
Gene symbol Pdcd6
Other names/aliases AV299538
Alg2
MA-3
PS2
alg-2
Species Mus musculus
 Database cross references - Pdcd6
ExoCarta ExoCarta_18570
Vesiclepedia VP_18570
Entrez Gene 18570
UniProt P12815  
 Pdcd6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
Mov neuroglial cells 15210972    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdcd6
Molecular Function
    protein anchor GO:0043495 ISO
    protein dimerization activity GO:0046983 ISO
    calcium ion binding GO:0005509 IMP
    identical protein binding GO:0042802 ISO
    protein binding GO:0005515 IPI
    binding, bridging GO:0060090 ISO
    metal ion binding GO:0046872 IEA
    calcium-dependent protein binding GO:0048306 ISO
    protein homodimerization activity GO:0042803 IPI
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 IBA
Biological Process
    negative regulation of protein kinase B signaling GO:0051898 ISO
    apoptotic process GO:0006915 IDA
    proteolysis GO:0006508 IBA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 ISO
    angiogenesis GO:0001525 IEA
    response to calcium ion GO:0051592 IDA
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISO
    intracellular protein transport GO:0006886 ISO
    cellular response to heat GO:0034605 ISO
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    positive regulation of endothelial cell migration GO:0010595 ISO
    negative regulation of TOR signaling GO:0032007 ISO
    vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISO
    positive regulation of angiogenesis GO:0045766 ISO
Subcellular Localization
    endosome GO:0005768 IEA
    membrane GO:0016020 IEA
    endoplasmic reticulum GO:0005783 ISO
    nucleus GO:0005634 ISO
    endoplasmic reticulum exit site GO:0070971 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    cytoplasmic vesicle GO:0031410 ISO
 Experiment description of studies that identified Pdcd6 in exosomes
1
Experiment ID 907
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
EM
EV Biophysical techniques
CD81|FLOT1
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 39
MISEV standards
IEM
EV Biophysical techniques
TSG101|HSC70|FLOT1
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
4
Experiment ID 908
MISEV standards
EM
EV Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
HSPA5
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdcd6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdcd6 is involved
No pathways found





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