Gene description for IP6K1
Gene name inositol hexakisphosphate kinase 1
Gene symbol IP6K1
Other names/aliases IHPK1
PiUS
Species Homo sapiens
 Database cross references - IP6K1
ExoCarta ExoCarta_9807
Entrez Gene 9807
HGNC 18360
MIM 606991
UniProt Q92551  
 IP6K1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for IP6K1
Molecular Function
    inositol hexakisphosphate 5-kinase activity GO:0000832 IEA
    inositol hexakisphosphate 3-kinase activity GO:0052724 IEA
    inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440 IEA
    ATP binding GO:0005524 IEA
    inositol hexakisphosphate 1-kinase activity GO:0052723 IEA
Biological Process
    small molecule metabolic process GO:0044281 TAS
    inositol phosphate metabolic process GO:0043647 TAS
    phosphatidylinositol phosphorylation GO:0046854 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IP6K1 in exosomes
1
Experiment ID 234
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for IP6K1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EXOSC7 23016
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IP6K1 is involved
PathwayEvidenceSource
Synthesis of IPs in the nucleus TAS Reactome
Synthesis of pyrophosphates in the cytosol TAS Reactome





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