Gene description for IP6K1
Gene name inositol hexakisphosphate kinase 1
Gene symbol IP6K1
Other names/aliases IHPK1
PiUS
Species Homo sapiens
 Database cross references - IP6K1
ExoCarta ExoCarta_9807
Vesiclepedia VP_9807
Entrez Gene 9807
HGNC 18360
MIM 606991
UniProt Q92551  
 IP6K1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for IP6K1
Molecular Function
    inositol-1,3,4,5,6-pentakisphosphate kinase activity GO:0000827 TAS
    inositol hexakisphosphate kinase activity GO:0000828 IBA
    inositol hexakisphosphate kinase activity GO:0000828 IDA
    inositol hexakisphosphate kinase activity GO:0000828 TAS
    diphosphoinositol pentakisphosphate kinase activity GO:0000829 TAS
    inositol hexakisphosphate 5-kinase activity GO:0000832 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    inositol hexakisphosphate 1-kinase activity GO:0052723 IEA
    inositol 5-diphosphate pentakisphosphate 5-kinase activity GO:0052836 TAS
    diphosphoinositol tetrakisphosphate kinase activity GO:0052839 TAS
Biological Process
    inositol phosphate biosynthetic process GO:0032958 IBA
    inositol phosphate metabolic process GO:0043647 TAS
    phosphatidylinositol phosphate biosynthetic process GO:0046854 IBA
    phosphatidylinositol phosphate biosynthetic process GO:0046854 IDA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IP6K1 in exosomes
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for IP6K1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Two-hybrid Homo sapiens
2 EIF1AD 84285
Affinity Capture-MS Homo sapiens
3 IP6K2  
Affinity Capture-MS Homo sapiens
4 TFCP2 7024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GPS1 2873
Reconstituted Complex Homo sapiens
6 CACNA1A  
Two-hybrid Homo sapiens
7 GYPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 UBXN4 23190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SPATA6  
Affinity Capture-MS Homo sapiens
10 ADAMTSL4  
Two-hybrid Homo sapiens
11 TMEM134  
Affinity Capture-MS Homo sapiens
12 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CD6 923
Affinity Capture-MS Homo sapiens
14 RAB3IL1 5866
Reconstituted Complex Homo sapiens
15 FPR1  
Affinity Capture-MS Homo sapiens
16 STIM1 6786
Proximity Label-MS Homo sapiens
17 RBX1 9978
Affinity Capture-Western Homo sapiens
18 UBE4A 9354
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
19 DLX6  
Affinity Capture-MS Homo sapiens
20 EXOSC7 23016
Two-hybrid Homo sapiens
21 WIF1 11197
Affinity Capture-MS Homo sapiens
22 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
23 LRRC25  
Affinity Capture-MS Homo sapiens
24 FGFR2 2263
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 C3orf18  
Affinity Capture-MS Homo sapiens
26 VCP 7415
Affinity Capture-MS Homo sapiens
27 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DEFA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 DDB1 1642
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
30 COPS2 9318
Reconstituted Complex Homo sapiens
31 CLMP 79827
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SEC61B 10952
Affinity Capture-MS Homo sapiens
33 CUL4A 8451
Affinity Capture-Western Homo sapiens
34 ACBD5 91452
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here