Gene description for SLC9A6
Gene name solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
Gene symbol SLC9A6
Other names/aliases MRSA
NHE6
Species Homo sapiens
 Database cross references - SLC9A6
ExoCarta ExoCarta_10479
Vesiclepedia VP_10479
Entrez Gene 10479
HGNC 11079
MIM 300231
UniProt Q92581  
 SLC9A6 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC9A6
Molecular Function
    protein binding GO:0005515 IPI
    sodium:proton antiporter activity GO:0015385 IBA
    sodium:proton antiporter activity GO:0015385 TAS
    potassium:proton antiporter activity GO:0015386 IBA
    identical protein binding GO:0042802 IDA
Biological Process
    monoatomic ion transport GO:0006811 TAS
    establishment of cell polarity GO:0030010 IMP
    axon extension GO:0048675 IDA
    neuron projection morphogenesis GO:0048812 IDA
    regulation of intracellular pH GO:0051453 IBA
    regulation of intracellular pH GO:0051453 IDA
    regulation of intracellular pH GO:0051453 IMP
    potassium ion transmembrane transport GO:0071805 IBA
    dendrite extension GO:0097484 IDA
    sodium ion import across plasma membrane GO:0098719 IBA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    early endosome membrane GO:0031901 IDA
    early endosome membrane GO:0031901 TAS
    late endosome membrane GO:0031902 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome GO:0055037 IBA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified SLC9A6 in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC9A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMEM164  
Affinity Capture-MS Homo sapiens
2 TMEM87A 25963
Affinity Capture-MS Homo sapiens
3 FNDC4 64838
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 LGALS9 3965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC31A2  
Affinity Capture-MS Homo sapiens
6 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CLGN 1047
Affinity Capture-MS Homo sapiens
8 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CANX 821
Affinity Capture-MS Homo sapiens
10 VAT1L 57687
Affinity Capture-MS Homo sapiens
11 YIPF6 286451
Affinity Capture-MS Homo sapiens
12 VSIG1  
Affinity Capture-MS Homo sapiens
13 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SLC39A8 64116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FKRP 79147
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SLC1A5 6510
Affinity Capture-MS Homo sapiens
17 FUT8 2530
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LGALS9B 284194
Affinity Capture-MS Homo sapiens
19 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
20 IFNGR1 3459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SLC19A2 10560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 POMGNT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SERINC1 57515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RELL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 FGFR2 2263
Affinity Capture-MS Homo sapiens
27 TBC1D32 221322
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SPCS1 28972
Affinity Capture-MS Homo sapiens
29 MAN2A2 4122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CMTM5  
Affinity Capture-MS Homo sapiens
31 ALDH3B1 221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 RAC3 5881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SLC9A7 84679
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CDK20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KIR2DL4  
Affinity Capture-MS Homo sapiens
36 YIPF3 25844
Affinity Capture-MS Homo sapiens
37 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 DNAJC30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PLD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 COA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TLCD2  
Affinity Capture-MS Homo sapiens
42 MAP1LC3B2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GALNT14  
Affinity Capture-MS Homo sapiens
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