Gene description for FKRP
Gene name fukutin related protein
Gene symbol FKRP
Other names/aliases LGMD2I
MDC1C
MDDGA5
MDDGB5
MDDGC5
Species Homo sapiens
 Database cross references - FKRP
ExoCarta ExoCarta_79147
Vesiclepedia VP_79147
Entrez Gene 79147
HGNC 17997
MIM 606596
UniProt Q9H9S5  
 FKRP identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FKRP
Molecular Function
    dystroglycan binding GO:0002162 IEA
    protein binding GO:0005515 IPI
    phosphotransferase activity, for other substituted phosphate groups GO:0016780 IDA
    identical protein binding GO:0042802 IPI
    laminin binding GO:0043236 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    in utero embryonic development GO:0001701 IEA
    neuron migration GO:0001764 IEA
    heart morphogenesis GO:0003007 IEA
    respiratory system process GO:0003016 IEA
    glycolytic process GO:0006096 IEA
    creatine metabolic process GO:0006600 IEA
    lipid metabolic process GO:0006629 IEA
    muscle contraction GO:0006936 IEA
    inflammatory response GO:0006954 IEA
    brain development GO:0007420 IEA
    adult walking behavior GO:0007628 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    glial cell differentiation GO:0010001 IEA
    response to activity GO:0014823 IEA
    protein processing GO:0016485 IEA
    protein import GO:0017038 IEA
    pentose metabolic process GO:0019321 IEA
    pentitol metabolic process GO:0019519 IEA
    bone mineralization GO:0030282 IEA
    protein O-linked mannosylation GO:0035269 IBA
    protein O-linked mannosylation GO:0035269 IMP
    maintenance of protein localization in endoplasmic reticulum GO:0035437 IEA
    filtration diaphragm assembly GO:0036058 IEA
    reelin-mediated signaling pathway GO:0038026 IEA
    camera-type eye development GO:0043010 IEA
    skeletal muscle tissue regeneration GO:0043403 IEA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA
    neuromuscular process GO:0050905 IEA
    protein tetramerization GO:0051262 IDA
    response to glucocorticoid GO:0051384 IEA
    localization of cell GO:0051674 IEA
    diaphragm development GO:0060539 IEA
    connective tissue development GO:0061448 IEA
    basement membrane organization GO:0071711 IEA
    oxygen metabolic process GO:0072592 IEA
    response to alcohol GO:0097305 IEA
    connective tissue replacement GO:0097709 IEA
    skeletal muscle fiber differentiation GO:0098528 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    extracellular space GO:0005615 IDA
    nucleoplasm GO:0005654 IDA
    rough endoplasmic reticulum GO:0005791 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    sarcolemma GO:0042383 IEA
    skeletal muscle myofibril GO:0098723 IEA
 Experiment description of studies that identified FKRP in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FKRP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Affinity Capture-MS Homo sapiens
2 GPM6A 2823
Affinity Capture-MS Homo sapiens
3 LHFPL4  
Affinity Capture-MS Homo sapiens
4 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 VNN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 STAT6 6778
Affinity Capture-MS Homo sapiens
7 TMEM59 9528
Affinity Capture-MS Homo sapiens
8 TTYH1  
Affinity Capture-MS Homo sapiens
9 SIDT2 51092
Affinity Capture-MS Homo sapiens
10 IGHD  
Affinity Capture-MS Homo sapiens
11 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NIPAL1  
Affinity Capture-MS Homo sapiens
13 KEAP1 9817
Negative Genetic Homo sapiens
14 CD1B 910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SYNE4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SLC7A14  
Affinity Capture-MS Homo sapiens
19 PARK2  
Affinity Capture-MS Homo sapiens
20 ITFG3 83986
Affinity Capture-MS Homo sapiens
21 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KDSR 2531
Affinity Capture-MS Homo sapiens
24 SAAL1 113174
Affinity Capture-MS Homo sapiens
25 B3GNT2 10678
Affinity Capture-MS Homo sapiens
26 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ELANE 1991
Affinity Capture-MS Homo sapiens
29 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SEC62 7095
Affinity Capture-MS Homo sapiens
31 RHOT2 89941
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SLC9A6 10479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ABHD14A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FKRP is involved
No pathways found





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