Gene description for FNDC4
Gene name fibronectin type III domain containing 4
Gene symbol FNDC4
Other names/aliases FRCP1
Species Homo sapiens
 Database cross references - FNDC4
ExoCarta ExoCarta_64838
Vesiclepedia VP_64838
Entrez Gene 64838
HGNC 20239
MIM 611905
UniProt Q9H6D8  
 FNDC4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for FNDC4
Biological Process
    negative regulation of inflammatory response GO:0050728 ISS
    response to transforming growth factor beta GO:0071559 IEP
Subcellular Localization
    extracellular space GO:0005615 ISS
    endoplasmic reticulum GO:0005783 ISS
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified FNDC4 in exosomes
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FNDC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2G 5436
Two-hybrid Homo sapiens
2 REEP3 221035
Affinity Capture-MS Homo sapiens
3 LIMA1 51474
Affinity Capture-MS Homo sapiens
4 ND2 4536
Affinity Capture-MS Homo sapiens
5 PIGU 128869
Affinity Capture-MS Homo sapiens
6 GPR89B 51463
Affinity Capture-MS Homo sapiens
7 NDUFB3 4709
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MPRIP 23164
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ALG10  
Affinity Capture-MS Homo sapiens
10 GALNT11 63917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SAFB2 9667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CAV1 857
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
14 SLC9A6 10479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TRPM4 54795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 AGPAT3 56894
Affinity Capture-MS Homo sapiens
17 PPP1R10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 INTS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GHITM 27069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ND5 4540
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FNDC4 is involved
No pathways found





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