Gene description for SLC9A7
Gene name solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
Gene symbol SLC9A7
Other names/aliases NHE-7
NHE7
SLC9A6
Species Homo sapiens
 Database cross references - SLC9A7
ExoCarta ExoCarta_84679
Vesiclepedia VP_84679
Entrez Gene 84679
HGNC 17123
MIM 300368
UniProt Q96T83  
 SLC9A7 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC9A7
Molecular Function
    protein binding GO:0005515 IPI
    sodium:proton antiporter activity GO:0015385 IBA
    sodium:proton antiporter activity GO:0015385 IDA
    sodium:proton antiporter activity GO:0015385 TAS
    potassium:proton antiporter activity GO:0015386 IBA
    potassium:proton antiporter activity GO:0015386 IDA
Biological Process
    monoatomic ion transport GO:0006811 TAS
    regulation of pH GO:0006885 IDA
    regulation of intracellular pH GO:0051453 IBA
    potassium ion transmembrane transport GO:0071805 IBA
    sodium ion import across plasma membrane GO:0098719 IBA
    proton transmembrane transport GO:1902600 IEA
    regulation of Golgi lumen acidification GO:1905526 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome GO:0055037 IBA
    recycling endosome membrane GO:0055038 IDA
 Experiment description of studies that identified SLC9A7 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC9A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPR35  
Two-hybrid Homo sapiens
2 SLC9A6 10479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 RAB4A 5867
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here