Gene description for FOXP2
Gene name forkhead box P2
Gene symbol FOXP2
Other names/aliases CAGH44
SPCH1
TNRC10
Species Homo sapiens
 Database cross references - FOXP2
ExoCarta ExoCarta_93986
Entrez Gene 93986
HGNC 13875
MIM 605317
UniProt O15409  
 FOXP2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FOXP2
Molecular Function
    metal ion binding GO:0046872 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IEA
    protein heterodimerization activity GO:0046982 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    protein homodimerization activity GO:0042803 IDA
Biological Process
    putamen development GO:0021758 IMP
    smooth muscle tissue development GO:0048745 IEA
    skeletal muscle tissue development GO:0007519 IEA
    vocal learning GO:0042297 IEA
    positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    cerebellum development GO:0021549 IEA
    righting reflex GO:0060013 IEA
    caudate nucleus development GO:0021757 IMP
    lung alveolus development GO:0048286 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    post-embryonic development GO:0009791 IEA
    camera-type eye development GO:0043010 IEA
    growth GO:0040007 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    transcription, DNA-templated GO:0006351 IEA
    cerebral cortex development GO:0021987 IEP
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified FOXP2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FOXP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTBP1 1487
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
2 FOXP4  
Affinity Capture-Western Homo sapiens
3 FOXP1 27086
Affinity Capture-Western Homo sapiens
4 FOXP2 93986
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which FOXP2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here