Gene description for TNFSF13
Gene name tumor necrosis factor (ligand) superfamily, member 13
Gene symbol TNFSF13
Other names/aliases APRIL
CD256
TALL-2
TALL2
TRDL-1
UNQ383/PRO715
ZTNF2
Species Homo sapiens
 Database cross references - TNFSF13
ExoCarta ExoCarta_8741
Entrez Gene 8741
HGNC 11928
MIM 604472
UniProt O75888  
 TNFSF13 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TNFSF13
Molecular Function
    cytokine activity GO:0005125 IEA
    receptor binding GO:0005102 TAS
    tumor necrosis factor receptor binding GO:0005164 IEA
Biological Process
    positive regulation of isotype switching to IgA isotypes GO:0048298 IDA
    signal transduction GO:0007165 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    gene expression GO:0010467 TAS
    positive regulation of germinal center formation GO:0002636 IEA
    immunoglobulin production in mucosal tissue GO:0002426 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 TAS
    external side of plasma membrane GO:0009897 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified TNFSF13 in exosomes
1
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TNFSF13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XPO1 7514
Affinity Capture-Western Homo sapiens
2 TNFRSF17  
Invitro Homo sapiens
3 TNFRSF1A 7132
Invitro Homo sapiens
4 TNFSF13B  
Invitro Homo sapiens
5 TNFRSF14  
Invitro Homo sapiens
6 TNFRSF11B 4982
Invitro Homo sapiens
7 FAS 355
Invitro Homo sapiens
8 TNFRSF13B  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TNFSF13 is involved
PathwayEvidenceSource
HuR stabilizes mRNA TAS Reactome





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