Gene description for TNFSF13
Gene name tumor necrosis factor (ligand) superfamily, member 13
Gene symbol TNFSF13
Other names/aliases APRIL
CD256
TALL-2
TALL2
TRDL-1
UNQ383/PRO715
ZTNF2
Species Homo sapiens
 Database cross references - TNFSF13
ExoCarta ExoCarta_8741
Vesiclepedia VP_8741
Entrez Gene 8741
HGNC 11928
MIM 604472
UniProt O75888  
 TNFSF13 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TNFSF13
Molecular Function
    signaling receptor binding GO:0005102 TAS
    cytokine activity GO:0005125 IEA
    tumor necrosis factor receptor binding GO:0005164 IEA
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IBA
Biological Process
    immune response GO:0006955 IEA
    signal transduction GO:0007165 TAS
    positive regulation of cell population proliferation GO:0008284 TAS
    positive regulation of B cell proliferation GO:0030890 IBA
    positive regulation of isotype switching to IgA isotypes GO:0048298 IBA
    positive regulation of isotype switching to IgA isotypes GO:0048298 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TNFSF13 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TNFSF13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LRRC15 131578
Affinity Capture-MS Homo sapiens
2 HSPA5 3309
Affinity Capture-MS Homo sapiens
3 FAS 355
Reconstituted Complex Homo sapiens
4 RUVBL2 10856
Affinity Capture-MS Homo sapiens
5 DPCD  
Affinity Capture-MS Homo sapiens
6 CAMK1D 57118
Two-hybrid Homo sapiens
7 PON2 5445
Affinity Capture-MS Homo sapiens
8 TUBB8 347688
Affinity Capture-MS Homo sapiens
9 TNFRSF1A 7132
Reconstituted Complex Homo sapiens
10 VSIG8  
Affinity Capture-MS Homo sapiens
11 FASTKD3  
Affinity Capture-MS Homo sapiens
12 FKBP14  
Affinity Capture-MS Homo sapiens
13 SGTB  
Two-hybrid Homo sapiens
14 TNFSF13 8741
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 RUVBL1 8607
Affinity Capture-MS Homo sapiens
16 TNFRSF11B 4982
Reconstituted Complex Homo sapiens
17 SELENBP1 8991
Affinity Capture-MS Homo sapiens
18 CLSTN3 9746
Affinity Capture-MS Homo sapiens
19 DUSP14 11072
Affinity Capture-MS Homo sapiens
20 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
21 DSC2 1824
Affinity Capture-MS Homo sapiens
22 SUMF1 285362
Affinity Capture-MS Homo sapiens
23 TNFSF13B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 AGPAT2  
Affinity Capture-MS Homo sapiens
25 TNFRSF14  
Reconstituted Complex Homo sapiens
26 TNFRSF13B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 YIF1B 90522
Affinity Capture-MS Homo sapiens
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