Gene description for TNFRSF11B
Gene name tumor necrosis factor receptor superfamily, member 11b
Gene symbol TNFRSF11B
Other names/aliases OCIF
OPG
TR1
Species Homo sapiens
 Database cross references - TNFRSF11B
ExoCarta ExoCarta_4982
Entrez Gene 4982
HGNC 11909
MIM 602643
UniProt O00300  
 TNFRSF11B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TNFRSF11B
Molecular Function
    receptor activity GO:0004872 TAS
    cytokine activity GO:0005125 TAS
Biological Process
    signal transduction GO:0007165 IEA
    response to magnesium ion GO:0032026 IEA
    response to nutrient GO:0007584 IEA
    response to estrogen GO:0043627 IEA
    skeletal system development GO:0001501 TAS
    extracellular matrix organization GO:0030198 IEA
    response to drug GO:0042493 IEA
    response to arsenic-containing substance GO:0046685 IEA
    negative regulation of bone resorption GO:0045779 IEA
    negative regulation of odontogenesis of dentin-containing tooth GO:0042489 IEA
    apoptotic process GO:0006915 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular region GO:0005576 TAS
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified TNFRSF11B in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TNFRSF11B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFSF12-TNFSF13  
Invitro Homo sapiens
2 TNFSF13 8741
Invitro Homo sapiens
3 TNFSF11  
Reconstituted Complex Homo sapiens
4 TNFSF10 8743
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TNFRSF11B is involved
No pathways found





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