Gene description for DIP2A
Gene name DIP2 disco-interacting protein 2 homolog A (Drosophila)
Gene symbol DIP2A
Other names/aliases C21orf106
DIP2
Species Homo sapiens
 Database cross references - DIP2A
ExoCarta ExoCarta_23181
Entrez Gene 23181
HGNC 17217
MIM 607711
UniProt Q14689  
 DIP2A identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Neuroblastoma cells 25944692    
 Gene ontology annotations for DIP2A
Molecular Function
    catalytic activity GO:0003824 IEA
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IEA
Biological Process
    multicellular organismal development GO:0007275 IEA
    negative regulation of gene expression GO:0010629 IDA
    regulation of apoptotic process GO:0042981 IMP
    metabolic process GO:0008152 IEA
Subcellular Localization
    cell surface GO:0009986 IDA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified DIP2A in exosomes
1
Experiment ID 21
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DIP2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DAB2 1601
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DIP2A is involved
No pathways found





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